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    SDH7 Sdh7p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852123, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SDH7
    Official Full Name
    Sdh7p
    Primary source
    SGD:S000002919
    Locus tag
    YDR511W
    See related
    AllianceGenome:SGD:S000002919; FungiDB:YDR511W; VEuPathDB:YDR511W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ACN9
    Summary
    Involved in carbon utilization; mitochondrial respiratory chain complex II assembly; and regulation of gluconeogenesis. Located in mitochondrial intermembrane space. Used to study mitochondrial complex II deficiency; paraganglioma; and pheochromocytoma. Orthologous to human SDHAF3 (succinate dehydrogenase complex assembly factor 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SDH7 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1470017..1470418)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene glutamine permease GNP1 Neighboring gene SUMO family protein SMT3 Neighboring gene Emi1p Neighboring gene dithiol glutaredoxin GRX2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of SDHAF3 in familial and sporadic pheochromocytoma and paraganglioma. Dwight T, et al. BMC Cancer, 2017 Jul 24. PMID 28738844, Free PMC Article
    2. Acn9 is a novel protein of gluconeogenesis that is located in the mitochondrial intermembrane space. Dennis RA, et al. Eur J Biochem, 1999 Apr. PMID 10103055
    3. Yeast mutants of glucose metabolism with defects in the coordinate regulation of carbon assimilation. Dennis RA, et al. Arch Biochem Biophys, 1999 May 15. PMID 10328823
    4. ACP Acylation Is an Acetyl-CoA-Dependent Modification Required for Electron Transport Chain Assembly. Van Vranken JG, et al. Mol Cell, 2018 Aug 16. PMID 30118679, Free PMC Article
    5. Mutants of Saccharomyces cerevisiae with defects in acetate metabolism: isolation and characterization of Acn- mutants. McCammon MT. Genetics, 1996 Sep. PMID 8878673, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbon utilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex II assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex II assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respiratory chain complex II assembly IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in succinate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sdh7p
    NP_010799.3
    • Mitochondrial protein involved in assembly of succinate dehydrogenase; has a role in maturation of the Sdh2p subunit; localized to the mitochondrial intermembrane space; required for acetate utilization and gluconeogenesis; mutation in Drosophila ortholog SDHAF3 causes reduced succinate dehydrogenase activity and neuronal and muscular dysfunction; member of the LYR protein family

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1470017..1470418
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180819.3 → NP_010799.3  TPA: Sdh7p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010799.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTD2, Q02562, Q04401
      UniProtKB/TrEMBL
      A6ZZ99, B3LFF8, C7GKU5, C8Z668, G2WBN8, N1PAL6
      Conserved Domains (1) summary
      cd20270
      Location:23 → 79
      Complex1_LYR_SDHAF3_LYRM10; LYR (leucine-tyrosine-arginine) motif found in mitochondrial succinate dehydrogenase assembly factor 3 (SDHAF3) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04401.1

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