U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ERD1 Erd1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852023, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ERD1
    Official Full Name
    Erd1p
    Primary source
    SGD:S000002822
    Locus tag
    YDR414C
    See related
    AllianceGenome:SGD:S000002822; FungiDB:YDR414C; VEuPathDB:YDR414C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LDB2
    Summary
    Involved in protein retention in ER lumen. Acts upstream of or within protein glycosylation and retrograde transport, vesicle recycling within Golgi. Located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ERD1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1295598..1296686, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Dfm1p Neighboring gene Rrp17p Neighboring gene putative aminopeptidase Neighboring gene mRNA splicing protein SYF1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Sorting of soluble ER proteins in yeast. Pelham HR, et al. EMBO J, 1988 Jun. PMID 3049074, Free PMC Article
    2. Cloning and DNA sequence of a Kluyveromyces lactis ERD1 homologue. Dean N. Yeast, 1994 Aug. PMID 7992512
    3. ERD1, a yeast gene required for the retention of luminal endoplasmic reticulum proteins, affects glycoprotein processing in the Golgi apparatus. Hardwick KG, et al. EMBO J, 1990 Mar. PMID 2178921, Free PMC Article
    4. δ-COP contains a helix C-terminal to its longin domain key to COPI dynamics and function. Arakel EC, et al. Proc Natl Acad Sci U S A, 2016 Jun 21. PMID 27298352, Free PMC Article
    5. Characterization of aromatic residue-controlled protein retention in the endoplasmic reticulum of Saccharomyces cerevisiae. Mei M, et al. J Biol Chem, 2017 Dec 15. PMID 29038295, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Golgi membrane protein Erd1 Is essential for recycling a subset of Golgi glycosyltransferases.
      Title: Golgi membrane protein Erd1 Is essential for recycling a subset of Golgi glycosyltransferases.
    2. Erd1 transports Pi in the opposite direction from XPR1 and other EXS family proteins and facilitates byproduct removal from the Golgi complex together with Gdt1
      Title: H(+) and Pi Byproducts of Glycosylation Affect Ca(2+) Homeostasis and Are Retrieved from the Golgi Complex by Homologs of TMEM165 and XPR1.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein retention in ER lumen IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within retrograde transport, vesicle recycling within Golgi IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Erd1p
    NP_010702.4
    • Predicted membrane protein required for lumenal ER protein retention; Golgi inorganic phosphate (Pi) exporter that balances Pi import associated with NDP-sugar transport into the Golgi; involved in recycling of early glycosyltransferases from late to early Golgi compartments; mutants secrete the endogenous ER protein, BiP (Kar2p)

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1295598..1296686 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180722.4 → NP_010702.4  TPA: Erd1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010702.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT45, P16151
      UniProtKB/TrEMBL
      B3LFP1, B5VGU6, C7GY30, C8Z5X7, N1PAJ7
      Conserved Domains (1) summary
      cl03905
      Location:1 → 362
      EXS; EXS family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16151.3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools