DGK1 diacylglycerol kinase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: DGK1
Official Full Name: diacylglycerol kinase
Primary source: SGD:S000005838
Locus tag: YOR311C
See related: AllianceGenome:SGD:S000005838; FungiDB:YOR311C; VEuPathDB:YOR311C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: HSD1
Summary: Enables CTP-dependent diacylglycerol kinase activity. Involved in phosphatidic acid biosynthetic process and regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See DGK1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (899056..899928, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Diacylglycerol kinase alleviates autophagic degradation of the endoplasmic reticulum in SPT10-deficient yeast to enhance triterpene biosynthesis.
Title: Diacylglycerol kinase alleviates autophagic degradation of the endoplasmic reticulum in SPT10-deficient yeast to enhance triterpene biosynthesis.
This work demonstrates that the CKII-mediated phosphorylation of Dgk1 regulates its function in the production of Phosphatidic Acid
Title: Phosphorylation of Dgk1 Diacylglycerol Kinase by Casein Kinase II Regulates Phosphatidic Acid Production in Saccharomyces cerevisiae.
DGK1-encoded diacylglycerol kinase activity is required to convert triacylglycerol-derived diacylglycerol to phosphatidate for phospholipid synthesis
Title: DGK1-encoded diacylglycerol kinase activity is required for phospholipid synthesis during growth resumption from stationary phase in Saccharomyces cerevisiae.
Diacylglycerol kinase activity was stimulated by major membrane phospholipids and was inhibited by CDP-diacylglycerol and sphingoid bases
Title: Characterization of the yeast DGK1-encoded CTP-dependent diacylglycerol kinase.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP-dependent diacylglycerol kinase activity	IEA Inferred from Electronic Annotation more info
enables CTP-dependent diacylglycerol kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables CTP-dependent diacylglycerol kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables lipid kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in phosphatidic acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidic acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidic acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: diacylglycerol kinase

NP_014956.3

EC 2.7.1.174

Diacylglycerol kinase; localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures, stimulates the mevalonate/ergosterol pathway and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

899056..899928 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183731.3 → NP_014956.3 TPA: diacylglycerol kinase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014956.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W310, Q12382

UniProtKB/TrEMBL

B3LJX5, B5VSI8, C8ZH61, N1NYX9

Conserved Domains (1) summary

COG0170
Location:34 → 286

SEC59; Dolichol kinase [Posttranslational modification, protein turnover, chaperones]