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    VPS68 Vps68p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853991, updated on 27-Dec-2024

    Summary

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    Official Symbol
    VPS68
    Official Full Name
    Vps68p
    Primary source
    SGD:S000005489
    Locus tag
    YOL129W
    See related
    AllianceGenome:SGD:S000005489; FungiDB:YOL129W; VEuPathDB:YOL129W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in late endosome to vacuole transport via multivesicular body sorting pathway. Located in fungal-type vacuole membrane. Part of Vps55/Vps68 complex. Is active in endosome. Orthologous to several human genes including TMEM50B (transmembrane protein 50B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VPS68 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (77560..78114)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Mg(2+) transporter ALR1 Neighboring gene serine/threonine protein kinase YGK3 Neighboring gene ribosomal 60S subunit protein L25

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Global analysis of yeast endosomal transport identifies the vps55/68 sorting complex. Schluter C, et al. Mol Biol Cell, 2008 Apr. PMID 18216282, Free PMC Article
    2. Interaction between ESCRT-III proteins and the yeast SERINC homolog Tms1. Kölling R. Genetics, 2024 Oct 7. PMID 39271159
    3. Organelle acidification is important for localisation of vacuolar proteins in Saccharomyces cerevisiae. Matsumoto R, et al. Protoplasma, 2013 Dec. PMID 23708375
    4. Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Bonangelino CJ, et al. Mol Biol Cell, 2002 Jul. PMID 12134085, Free PMC Article
    5. VID22 counteracts G-quadruplex-induced genome instability. Galati E, et al. Nucleic Acids Res, 2021 Dec 16. PMID 34871443, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Vps55p and Vps68p form a complex that acts with or downstream of ESCRT function to regulate endosomal trafficking.
      Title: Global analysis of yeast endosomal transport identifies the vps55/68 sorting complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to vacuole HMP PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Vps55/Vps68 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Vps55/Vps68 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Vps55/Vps68 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vps68p
    NP_014512.1
    • Vacuolar membrane hypothetical protein; involved in vacuolar protein sorting; also detected in the mitochondria

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      77560..78114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183383.1 → NP_014512.1  TPA: Vps68p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014512.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1T9, Q12016
      UniProtKB/TrEMBL
      A6ZN82, B3LIT7, B5VRC9, C7GV05, C8ZHI7, G2WMA8, N1NWR6
      Conserved Domains (1) summary
      pfam05255
      Location:11 → 178
      UPF0220; Uncharacterized protein family (UPF0220)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12016.1

    Gene LinkOut

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