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    COX8 cytochrome c oxidase subunit VIII [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851111, updated on 9-Dec-2024

    Summary

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    Official Symbol
    COX8
    Official Full Name
    cytochrome c oxidase subunit VIII
    Primary source
    SGD:S000004387
    Locus tag
    YLR395C
    See related
    AllianceGenome:SGD:S000004387; FungiDB:YLR395C; VEuPathDB:YLR395C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to cytochrome-c oxidase activity. Involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion. Part of respiratory chain complex IV. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See COX8 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (909729..909965, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Atp10p Neighboring gene SUMO ligase CST9 Neighboring gene tethering complex ATP-binding subunit VPS33 Neighboring gene AAA family ATPase AFG2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. COX8, the structural gene for yeast cytochrome c oxidase subunit VIII. DNA sequence and gene disruption indicate that subunit VIII is required for maximal levels of cellular respiration and is derived from a precursor which is extended at both its NH2 and COOH termini. Patterson TE, et al. J Biol Chem, 1986 Dec 25. PMID 3023386
    2. The nuclear-coded subunits of yeast cytochrome c oxidase. II. The amino acid sequence of subunit VIII and a model for its disposition in the inner mitochondrial membrane. Power SD, et al. J Biol Chem, 1984 May 25. PMID 6327685
    3. The nuclear-coded subunits of yeast cytochrome c oxidase. The amino acid sequences of subunits VII and VIIa, structural similarities between the three smallest polypeptides of the holoenzyme, and implications for biogenesis. Power SD, et al. J Biol Chem, 1986 Jul 15. PMID 3013877
    4. The nuclear-coded subunits of yeast cytochrome c oxidase. I. Fractionation of the holoenzyme into chemically pure polypeptides and the identification of two new subunits using solvent extraction and reversed phase high performance liquid chromatography. Power SD, et al. J Biol Chem, 1984 May 25. PMID 6327684
    5. Effects of oxygen concentration on the expression of cytochrome c and cytochrome c oxidase genes in yeast. Burke PV, et al. J Biol Chem, 1997 Jun 6. PMID 9169434

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to cytochrome-c oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oxidative phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex IV IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex IV IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit VIII
    NP_013499.1
    • Subunit VIII of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      909729..909965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182283.1 → NP_013499.1  TPA: cytochrome c oxidase subunit VIII [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013499.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ30, P04039
      UniProtKB/TrEMBL
      A7A1S0, B3RHR0, C7GXJ9, C8ZE04, G2WJL0, N1P060
      Conserved Domains (1) summary
      pfam02935
      Location:26 → 74
      COX7C; Cytochrome c oxidase subunit VIIc
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04039.2

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