Agap1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Agap1provided by MGI
Official Full Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 1provided by MGI
Primary source: MGI:MGI:2653690
See related: Ensembl:ENSMUSG00000055013 AllianceGenome:MGI:2653690
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ggap1; Centg2; mKIAA1099
Summary: Predicted to enable GTPase activator activity; GTPase activity; and phospholipid binding activity. Predicted to be involved in protein transport. Predicted to be located in cytosol. Is expressed in several structures, including central nervous system; peripheral nervous system ganglion; sensory organ; tooth; and vibrissa. Orthologous to several human genes including AGAP1 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 13.5), cerebellum adult (RPKM 12.8) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 D; 1 45.06 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (89382533..89823004)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (89454811..89895282)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.
Title: GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.
The elimination of adaptor protein 3 or abrogation of AGAP1-M5 muscarinic receptor interaction in vivo decreased the magnitude of presynaptic M5 muscarinic receptor mediated dopamine release potentiation in the striatum.
Title: AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.
AGAP1 is a novel binding partner of nitric oxide-sensitive guanylyl cyclase
Title: AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:234171 (e-PCR)
- UniSTS:234171

RH125215 (e-PCR)
- UniSTS:162037

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

Names: AGAP-1; centaurin-gamma-2; cnt-g2

NP_001032213.1

EC 3.6.5.2

NP_835220.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037136.1 → NP_001032213.1 arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AC124227, AK046523, AK147503

Consensus CDS

CCDS15148.1

UniProtKB/TrEMBL

A0A087WRF2, Q3UH88

Related

ENSMUSP00000140599.2, ENSMUST00000190096.7

Conserved Domains (8) summary

cd04103
Location:72 → 229

Centaurin_gamma; Centaurin gamma (CENTG) GTPase

smart00173
Location:73 → 235

RAS; Ras subfamily of RAS small GTPases

cd00204
Location:683 → 772

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01250
Location:344 → 539

PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain

pfam00169
Location:347 → 411

PH; PH domain

pfam01412
Location:558 → 672

ArfGap; Putative GTPase activating protein for Arf

pfam12796
Location:683 → 773

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:715 → 746

ANK; ANK repeat [structural motif]
NM_178119.3 → NP_835220.1 arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform 1

See identical proteins and their annotated locations for NP_835220.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).

Source sequence(s)

AC124227, AK046523, AK147503

Consensus CDS

CCDS15149.1

UniProtKB/Swiss-Prot

Q3UHA0, Q6ZPX9, Q8BXK8, Q8BZG0

Related

ENSMUSP00000027521.9, ENSMUST00000027521.15

Conserved Domains (8) summary

cd04103
Location:72 → 229

Centaurin_gamma; Centaurin gamma (CENTG) GTPase

smart00173
Location:73 → 235

RAS; Ras subfamily of RAS small GTPases

cd00204
Location:736 → 825

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01250
Location:344 → 592

PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain

pfam00169
Location:347 → 411

PH; PH domain

pfam01412
Location:611 → 725

ArfGap; Putative GTPase activating protein for Arf

pfam12796
Location:736 → 826

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:768 → 799

ANK; ANK repeat [structural motif]