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    SCS22 phospholipid metabolism-regulating protein SCS22 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852186, updated on 17-Dec-2024

    Summary

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    Official Symbol
    SCS22
    Official Full Name
    phospholipid metabolism-regulating protein SCS22
    Primary source
    SGD:S000007228
    Locus tag
    YBL091C-A
    See related
    AllianceGenome:SGD:S000007228; FungiDB:YBL091C-A; VEuPathDB:YBL091C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable protein-membrane adaptor activity. Involved in endoplasmic reticulum membrane organization; phospholipid biosynthetic process; and regulation of phosphatidylinositol dephosphorylation. Acts upstream of or within reticulophagy. Located in cytosol. Used to study amyotrophic lateral sclerosis type 8. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 8; autosomal dominant adult-onset proximal spinal muscular atrophy; and spinal muscular atrophy. Orthologous to human VAPA (VAMP associated protein A) and VAPB (VAMP associated protein B and C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SCS22 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_001134.8 (46565..47180, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Rox3p Neighboring gene ribosomal 60S subunit protein L32 Neighboring gene methionine aminopeptidase Neighboring gene mitochondrial 37S ribosomal protein MRP21

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A highly conserved binding site in vesicle-associated membrane protein-associated protein (VAP) for the FFAT motif of lipid-binding proteins. Loewen CJ, et al. J Biol Chem, 2005 Apr 8. PMID 15668246
    2. The yeast VAPs Scs2 and Scs22 are required for NVJ integrity and micronucleophagy. Manik MIN, et al. Biochem Biophys Res Commun, 2024 Nov 19. PMID 39232457
    3. The leucine zipper domain of the transcriptional repressor Opi1 underlies a signal transduction mechanism regulating lipid synthesis. Fernández-Murray JP, et al. J Biol Chem, 2023 Dec. PMID 37918807, Free PMC Article
    4. Cloning and sequence of the SCS2 gene, which can suppress the defect of INO1 expression in an inositol auxotrophic mutant of Saccharomyces cerevisiae. Nikawa J, et al. J Biochem, 1995 Jul. PMID 8537323
    5. Tricalbin-Mediated Contact Sites Control ER Curvature to Maintain Plasma Membrane Integrity. Collado J, et al. Dev Cell, 2019 Nov 18. PMID 31743662, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The yeast VAPs Scs2 and Scs22 are required for NVJ integrity and micronucleophagy.
      Title: The yeast VAPs Scs2 and Scs22 are required for NVJ integrity and micronucleophagy.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum membrane organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endoplasmic reticulum-plasma membrane tethering IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of phosphatidylinositol dephosphorylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within reticulophagy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid metabolism-regulating protein SCS22
    NP_009461.2
    • Cytosolic protein involved in the regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect the ER and plasma membrane (PM); regulates PI4P levels by controlling access of Sac1p to PM substrate PI4P; VAMP-associated protein (VAP) homolog; role in NVJ integrity and micronucleophagy; SCS22 has a paralog, SCS2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      46565..47180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184321.1 → NP_009461.2  TPA: phospholipid metabolism-regulating protein SCS22 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009461.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPR2, Q6Q595
      UniProtKB/TrEMBL
      B3LNM3, C8Z3V3, N1PAR6
      Conserved Domains (1) summary
      pfam00635
      Location:1 → 107
      Motile_Sperm; MSP (Major sperm protein) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6Q595.2

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