ECM27 Ecm27p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ECM27
Official Full Name: Ecm27p
Primary source: SGD:S000003867
Locus tag: YJR106W
See related: AllianceGenome:SGD:S000003867; FungiDB:YJR106W; VEuPathDB:YJR106W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable monoatomic cation transmembrane transporter activity. Involved in intracellular calcium ion homeostasis and regulation of G0 to G1 transition. Located in endoplasmic reticulum. Orthologous to human SLC8B1 (solute carrier family 8 member B1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ECM27 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (624838..627015)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results show that Ecm27p and Ca(2+) play roles in maintaining a high level of trehalose in quiescent cells, which in turn is important in the ability of cells to rapidly return to proliferation.
Title: Functions of Saccharomyces cerevisiae Ecm27p, a putative Na(+)/Ca(2+) exchanger, in calcium homeostasis, carbohydrate storage and cell cycle reentry from the quiescent phase.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables monoatomic cation transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic cation transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of G0 to G1 transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ecm27p

NP_012640.4

Protein involved in calcium homeostasis and exit from quiescence; required for proper trehalose levels during quiescence; may play a role in cell wall biosynthesis, mutants are hypersensitive to antifungal, Papulacandin B; null mutants have increased plasmid loss; interacts with Pdr5p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

624838..627015

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181764.4 → NP_012640.4 TPA: Ecm27p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012640.4

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWS5, P47144

UniProtKB/TrEMBL

C7GMA2, N1P8U9

Conserved Domains (2) summary

PLN03151
Location:544 → 637

PLN03151; cation/calcium exchanger; Provisional

COG0530
Location:18 → 225

ECM27; Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]