Naa20 N(alpha)-acetyltransferase 20, NatB catalytic subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Naa20provided by MGI
Official Full Name: N(alpha)-acetyltransferase 20, NatB catalytic subunitprovided by MGI
Primary source: MGI:MGI:1915127
See related: Ensembl:ENSMUSG00000002728 AllianceGenome:MGI:1915127
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nat5; D2Ertd186e; 1500004D14Rik; 2900026I01Rik
Summary: Predicted to enable peptide alpha-N-acetyltransferase activity. Predicted to be involved in N-terminal protein amino acid acetylation and regulation of actin cytoskeleton organization. Predicted to be located in cytosol and nucleus. Predicted to be part of NatB complex. Is expressed in several structures, including brain; retina; skin; stomach; and submandibular gland primordium. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 73. Orthologous to human NAA20 (N-alpha-acetyltransferase 20, NatB catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 9.7), placenta adult (RPKM 9.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 G1; 2 71.28 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (145743454..145758345)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (145901539..145916425)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NAA20 recruits Rin2 and promotes triple-negative breast cancer progression by regulating Rab5A-mediated activation of EGFR signaling.
Title: NAA20 recruits Rin2 and promotes triple-negative breast cancer progression by regulating Rab5A-mediated activation of EGFR signaling.
Mdm20 is not necessarily co-expressed with Nat5 in the developing mouse brain.
Title: Spatio-temporal expression pattern of the NatB complex, Nat5/Mdm20 in the developing mouse brain: implications for co-operative versus non-co-operative actions of Mdm20 and Nat5.
ARD1 functions as an inhibitor of the mTOR pathway and that dysregulation of the ARD1-TSC2-mTOR axis may contribute to cancer development
Title: ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126398 (e-PCR)
- UniSTS:163106

AU022840 (e-PCR)
- UniSTS:207413

NoName (e-PCR)
- UniSTS:488766

AU041458 (e-PCR)
- UniSTS:165214

NoName (e-PCR)
- UniSTS:235930

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables peptide alpha-N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in N-terminal peptidyl-aspartic acid acetylation	ISO Inferred from Sequence Orthology more info
involved_in N-terminal peptidyl-aspartic acid acetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in N-terminal peptidyl-glutamic acid acetylation	ISO Inferred from Sequence Orthology more info
involved_in N-terminal peptidyl-glutamic acid acetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in N-terminal peptidyl-glutamine acetylation	ISO Inferred from Sequence Orthology more info
involved_in N-terminal peptidyl-glutamine acetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in N-terminal protein amino acid acetylation	ISO Inferred from Sequence Orthology more info
involved_in N-terminal protein amino acid acetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of NatB complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NatB complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: N-alpha-acetyltransferase 20

Names: N-acetyltransferase 5 (ARD1 homolog, S. cerevisiae); N-terminal acetyltransferase B complex catalytic subunit NAA20; N-terminal acetyltransferase B complex catalytic subunit NAT5; methionine N-acetyltransferase; natB catalytic subunit; natB complex subunit NAT5

NP_001135437.1

EC 2.3.1.254

NP_080701.1

EC 2.3.1.254

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001141965.2 → NP_001135437.1 N-alpha-acetyltransferase 20 isoform 1

See identical proteins and their annotated locations for NP_001135437.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).

Source sequence(s)

AL672100

Consensus CDS

CCDS50735.1

UniProtKB/Swiss-Prot

P61600, Q14B28, Q4VAC3

Related

ENSMUSP00000105627.2, ENSMUST00000110000.8

Conserved Domains (1) summary

COG0456
Location:1 → 156

RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
NM_026425.4 → NP_080701.1 N-alpha-acetyltransferase 20 isoform 2

See identical proteins and their annotated locations for NP_080701.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an in-frame alternate splice site in the coding region, compared to variant 1, and encodes a longer protein (isoform 2), compared to isoform 1.

Source sequence(s)

AL672100

Consensus CDS

CCDS16827.1

UniProtKB/TrEMBL

Q9DB82

Related

ENSMUSP00000002805.8, ENSMUST00000002805.14

Conserved Domains (1) summary

COG0456
Location:1 → 166

RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]