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    AIT1 Ait1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851374, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AIT1
    Official Full Name
    Ait1p
    Primary source
    SGD:S000002339
    Locus tag
    YDL180W
    See related
    AllianceGenome:SGD:S000002339; FungiDB:YDL180W; VEuPathDB:YDL180W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Acts upstream of or within negative regulation of TORC1 signaling. Located in fungal-type vacuole. Is active in fungal-type vacuole membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AIT1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (135896..137539)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene homocitrate synthase LYS20 Neighboring gene ATPase inhibitor Neighboring gene Pcl9p Neighboring gene D-lactate dehydrogenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ait1 regulates TORC1 signaling and localization in budding yeast. Wallace RL, et al. Elife, 2022 Sep 1. PMID 36047762, Free PMC Article
    2. Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes. Wuttke D, et al. PLoS Genet, 2012. PMID 22912585, Free PMC Article
    3. Regulation of stress response signaling by the N-terminal dishevelled/EGL-10/pleckstrin domain of Sst2, a regulator of G protein signaling in Saccharomyces cerevisiae. Burchett SA, et al. J Biol Chem, 2002 Jun 21. PMID 11940600
    4. Characterization of the interaction between Rfa1 and Rad24 in Saccharomyces cerevisiae. Piya G, et al. PLoS One, 2015. PMID 25719602, Free PMC Article
    5. Systematic genetic array analysis links the Saccharomyces cerevisiae SAGA/SLIK and NuA4 component Tra1 to multiple cellular processes. Hoke SM, et al. BMC Genet, 2008 Jul 10. PMID 18616809, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in fungal-type vacuole HDA PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ait1p
    NP_010101.1
    • G protein-coupled receptor-like protein; involved in negatively regulating TORC1 activity; green fluorescent protein (GFP)-fusion protein localizes to the vacuole

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      135896..137539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180240.1 → NP_010101.1  TPA: Ait1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010101.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRH2, Q12301
      UniProtKB/TrEMBL
      B3LH64, C8Z6C4, N1P8U3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12301.1

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