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    GYP8 GTPase-activating protein GYP8 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850517, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GYP8
    Official Full Name
    GTPase-activating protein GYP8
    Primary source
    SGD:S000001867
    Locus tag
    YFL027C
    See related
    AllianceGenome:SGD:S000001867; FungiDB:YFL027C; VEuPathDB:YFL027C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase activator activity. Involved in vesicle-mediated transport. Located in peroxisome. Human ortholog(s) of this gene implicated in Warburg micro syndrome 4. Orthologous to human TBC1D20 (TBC1 domain family member 20). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GYP8 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (80419..81912, complement)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene cyclin-dependent protein kinase-activating kinase CAK1 Neighboring gene putative ATP-binding cassette family ATPase CAF16 Neighboring gene alpha-factor pheromone receptor STE2 Neighboring gene Bst1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Significance of GTP hydrolysis in Ypt1p-regulated endoplasmic reticulum to Golgi transport revealed by the analysis of two novel Ypt1-GAPs. De Antoni A, et al. J Biol Chem, 2002 Oct 25. PMID 12189143
    2. A Rab GAP cascade defines the boundary between two Rab GTPases on the secretory pathway. Rivera-Molina FE, et al. Proc Natl Acad Sci U S A, 2009 Aug 25. PMID 19666511, Free PMC Article
    3. Analysis of subcellular localization and function of the yeast Rab6 homologue, Ypt6p, using a novel amino-terminal tagging strategy. Kawamura S, et al. Biochem Biophys Res Commun, 2014 Jul 18. PMID 24924636
    4. Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity. Tenreiro S, et al. Hum Mol Genet, 2016 Jan 15. PMID 26586132
    5. The Msb3/Gyp3 GAP controls the activity of the Rab GTPases Vps21 and Ypt7 at endosomes and vacuoles. Lachmann J, et al. Mol Biol Cell, 2012 Jul. PMID 22593206, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GTPase-activating protein GYP8
    NP_444296.1
    • GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport; localizes to the ER and peroxisomes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      80419..81912 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179939.1 → NP_444296.1  TPA: GTPase-activating protein GYP8 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_444296.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTK3, P43570
      UniProtKB/TrEMBL
      C7GY84, G2WDB4, N1P4L0
      Conserved Domains (1) summary
      COG5210
      Location:2 → 497
      COG5210; GTPase-activating protein [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43570.1

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