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    BNR1 formin BNR1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854647, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BNR1
    Official Full Name
    formin BNR1
    Primary source
    SGD:S000001421
    Locus tag
    YIL159W
    See related
    AllianceGenome:SGD:S000001421; FungiDB:YIL159W; VEuPathDB:YIL159W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables profilin binding activity. Involved in actin cytoskeleton organization; barbed-end actin filament capping; and cellular hyperosmotic response. Located in cell division site and cellular bud neck. Is active in cytosol. Human ortholog(s) of this gene implicated in autosomal dominant auditory neuropathy 1; autosomal dominant nonsyndromic deafness 1; primary ovarian insufficiency; primary ovarian insufficiency 2A; and sensorineural hearing loss. Orthologous to several human genes including DIAPH2 (diaphanous related formin 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BNR1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (41825..45952)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Smu2p Neighboring gene acetyl-CoA C-acyltransferase Neighboring gene Aim20p Neighboring gene Coa1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis formin AtFH6 is a plasma membrane-associated protein upregulated in giant cells induced by parasitic nematodes. Favery B, et al. Plant Cell, 2004 Sep. PMID 15319477, Free PMC Article
    2. The formin DAD domain plays dual roles in autoinhibition and actin nucleation. Gould CJ, et al. Curr Biol, 2011 Mar 8. PMID 21333540, Free PMC Article
    3. The yeast formin Bnr1p has two localization regions that show spatially and temporally distinct association with septin structures. Gao L, et al. Mol Biol Cell, 2010 Apr 1. PMID 20147448, Free PMC Article
    4. Yeast formins Bni1 and Bnr1 utilize different modes of cortical interaction during the assembly of actin cables. Buttery SM, et al. Mol Biol Cell, 2007 May. PMID 17344480, Free PMC Article
    5. Computational modeling highlights the role of the disordered Formin Homology 1 domain in profilin-actin transfer. Horan BG, et al. FEBS Lett, 2018 Jun. PMID 29754461, Free PMC Article

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Smy1 regulation of Bnr1 activity is required for efficient secretory vesicle traffic.
      Title: Common formin-regulating sequences in Smy1 and Bud14 are required for the control of actin cable assembly in vivo.
    2. F-actin stabilization is regulated by yeast formins Bni1p and Bnr1p
      Title: Importance of a Lys113-Glu195 intermonomer ionic bond in F-actin stabilization and regulation by yeast formins Bni1p and Bnr1p.
    3. Yor304c-a/Bil1 colocalizes with Bud6 and functions in the Bnr1 pathway for actin assembly
      Title: Ligand-induced activation of a formin-NPF pair leads to collaborative actin nucleation.
    4. During polarization, cells change from fast to slow cable dynamics through spatio-temporal regulation of Bni1, Bnr1 and Myo2.
      Title: Cortical actin dynamics driven by formins and myosin V.
    5. Bnr1p has two separable regions that each contribute to its bud neck localization
      Title: The yeast formin Bnr1p has two localization regions that show spatially and temporally distinct association with septin structures.
    6. Yeast expressing the nonlocalized actin nucleating/assembly formin homology (FH) 1-FH2 domains of Bnr1p or Bni1p as the sole formin grow well.
      Title: Polarized growth in budding yeast in the absence of a localized formin.
    7. BNI1 and BNR1 contribute to Bud6p-dependent microtubule-cortex interactions by controlling Bud6p localisation.
      Title: Dissecting the involvement of formins in Bud6p-mediated cortical capture of microtubules in S. cerevisiae.
    8. Bni1 and Bnr1 are regulated by Bud6
      Title: Differential activities and regulation of Saccharomyces cerevisiae formin proteins Bni1 and Bnr1 by Bud6.
    9. different formin isoforms have roles in maintaining stable and dynamic axes in the same yeast cell
      Title: Stable and dynamic axes of polarity use distinct formin isoforms in budding yeast.
    10. Bnr1 was confined to the bud neck and did not exchange with a cytoplasmic pool.
      Title: Yeast formins Bni1 and Bnr1 utilize different modes of cortical interaction during the assembly of actin cables.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables profilin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables profilin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in actin filament bundle assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in actin filament bundle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in barbed-end actin filament capping IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular hyperosmotic response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in formin-nucleated actin cable assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in formin-nucleated actin cable assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in formin-nucleated actin cable assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic actomyosin contractile ring assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic actomyosin contractile ring assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cellular bud neck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mating projection tip IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic actomyosin contractile ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    formin BNR1
    NP_012107.1
    • Formin; nucleates the formation of linear actin filaments; involved in processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables; activity is regulated by Hof1p and by the Bud14p-Kel1p-Kel2p complex; dephosphorylated and delocalized from the division site in a Glc7p/Ref2p-dependent manner; functionally redundant with BNI1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      41825..45952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179507.1 → NP_012107.1  TPA: formin BNR1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012107.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVC7, P40450
      UniProtKB/TrEMBL
      G2WFZ2, N1P0Y3
      Conserved Domains (1) summary
      pfam02181
      Location:868 → 1265
      FH2; Formin Homology 2 Domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40450.1

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