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    SHE3 She3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852427, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SHE3
    Official Full Name
    She3p
    Primary source
    SGD:S000000334
    Locus tag
    YBR130C
    See related
    AllianceGenome:SGD:S000000334; FungiDB:YBR130C; VEuPathDB:YBR130C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables sequence-specific mRNA binding activity. Involved in endoplasmic reticulum inheritance; intracellular mRNA localization; and mating type switching. Located in cellular bud tip. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SHE3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (495592..496869, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Atg14p Neighboring gene Opy1p Neighboring gene Ccz1p Neighboring gene Agp2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Formation of She2p tetramers is required for mRNA binding, mRNP assembly, and localization. Müller M, et al. RNA, 2009 Nov. PMID 19710186, Free PMC Article
    2. Monomeric myosin V uses two binding regions for the assembly of stable translocation complexes. Heuck A, et al. Proc Natl Acad Sci U S A, 2007 Dec 11. PMID 18056806, Free PMC Article
    3. Hooking She3p onto She2p for myosin-mediated cytoplasmic mRNA transport. Singh N, et al. Proc Natl Acad Sci U S A, 2015 Jan 6. PMID 25535369, Free PMC Article
    4. Nuclear transit of the RNA-binding protein She2 is required for translational control of localized ASH1 mRNA. Du TG, et al. EMBO Rep, 2008 Aug. PMID 18566598, Free PMC Article
    5. A cytoplasmic complex mediates specific mRNA recognition and localization in yeast. Müller M, et al. PLoS Biol, 2011 Apr. PMID 21526221, Free PMC Article

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that the degradation of She3 by Grr1 is required for optimal cell growth.
      Title: Identification of She3 as an SCF(Grr1) substrate in budding yeast.
    2. The cytoplasmic transport factor She3p displaces Loc1p from the ASH1 mRNP, allowing for the maturation of the localizing ASH1 mRNP.
      Title: Role of Loc1p in assembly and reorganization of nuclear ASH1 messenger ribonucleoprotein particles in yeast.
    3. The adapter protein She3p tightly binds to the Myo4p rod, forming a single-headed motor complex.
      Title: Two single-headed myosin V motors bound to a tetrameric adapter protein form a processive complex.
    4. The present study reveals that the current accepted model for ASH1 mRNA localization does not fully account for the function of She3p in ASH1 mRNA localization.
      Title: She3p possesses a novel activity required for ASH1 mRNA localization in Saccharomyces cerevisiae.
    5. continuous transport of mRNA by Myo4p-She3p in yeast is accomplished either by multiple high duty cycle monomers or by molecules that may be dimerized by She2p, the homodimeric downstream binding partner of She3p
      Title: She3p binds to the rod of yeast myosin V and prevents it from dimerizing, forming a single-headed motor complex.
    6. anchoring of ASH1 mRNA requires molecular remodeling of the Myo4p-She3p-She2p heterotrimeric complex, a process that is apparently altered when mRNA is artificially tethered to She2p.
      Title: ASH1 mRNA anchoring requires reorganization of the Myo4p-She3p-She2p transport complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum inheritance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum inheritance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mating type switching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    She3p
    NP_009688.3
    • Protein adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      495592..496869 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178478.3 → NP_009688.3  TPA: She3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009688.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3LN26, D3UEM3, D6VQC7, P38272
      UniProtKB/TrEMBL
      N1P8H3
      Conserved Domains (1) summary
      pfam17078
      Location:42 → 268
      SHE3; SWI5-dependent HO expression protein 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38272.1

    Gene LinkOut

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