SHP1 protein phosphatase regulator SHP1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: SHP1
Official Full Name: protein phosphatase regulator SHP1
Primary source: SGD:S000000154
Locus tag: YBL058W
See related: AllianceGenome:SGD:S000000154; FungiDB:YBL058W; VEuPathDB:YBL058W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: UBX1
Summary: Enables K48-linked polyubiquitin modification-dependent protein binding activity and protein phosphatase regulator activity. Involved in several processes, including macroautophagy; proteasomal protein catabolic process; and sister chromatid biorientation. Located in cytosol and nucleus. Orthologous to several human genes including UBXN2B (UBX domain protein 2B). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Multiple phosphorylation of the Cdc48/p97 cofactor protein Shp1/p47 occurs upon cell stress in budding yeast.
Title: Multiple phosphorylation of the Cdc48/p97 cofactor protein Shp1/p47 occurs upon cell stress in budding yeast.
Cdc48/Shp1 participates in dissociation of protein complexes to regulate their activity.
Title: Cdc48/Shp1 participates in dissociation of protein complexes to regulate their activity.
Cdc48 cofactor Shp1 regulates signal-induced SCF(Met30) disassembly.
Title: Cdc48 cofactor Shp1 regulates signal-induced SCF(Met30) disassembly.
UBX domain-containing proteins are involved in lipid homeostasis and stress responses
Title: UBX domain-containing proteins are involved in lipid homeostasis and stress responses in Pichia pastoris.
Data suggest that the Cdc48(Shp1) complex controls Glc7 activity by regulating its interaction with Glc8 and possibly further regulatory subunits.
Title: The budding yeast Cdc48(Shp1) complex promotes cell cycle progression by positive regulation of protein phosphatase 1 (Glc7).
Cdc48-Shp1 promotes nuclear accumulation of Glc7 to counteract Ipl1 activity.
Title: The AAA-ATPase Cdc48 and cofactor Shp1 promote chromosome bi-orientation by balancing Aurora B activity.
Data suggest that Shp1 and Ubx2 are adaptors for Cdc48-dependent protein degradation through the ubiquitin/proteasome pathway.
Title: Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables K48-linked polyubiquitin modification-dependent protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein phosphatase regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in ascospore formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycogen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear membrane reassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in piecemeal microautophagy of the nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sister chromatid biorientation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_009495.1

Substrate adaptor for Cdc48p; ubiquitin regulatory X (UBX) and Ub-associated (UBA) domain-containing protein that acts as a substrate recruiting cofactor; K48-specific Ub chain binding protein involved in ER-associated degradation (ERAD); positively regulates Glc7p protein phosphatase activity to promote growth and mitotic progression in complex with Cdc48p; regulated by nuclear Ub-dependent degradation (INMAD pathway) independent of the Asi and Doa10 complexes; homolog of human p47 (NSFL1C)

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