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    Smo smoothened, frizzled class receptor [ Mus musculus (house mouse) ]

    Gene ID: 319757, updated on 28-Jan-2025

    Summary

    Official Symbol
    Smoprovided by MGI
    Official Full Name
    smoothened, frizzled class receptorprovided by MGI
    Primary source
    MGI:MGI:108075
    See related
    Ensembl:ENSMUSG00000001761 AllianceGenome:MGI:108075
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    bnb; Smoh; smoothened; E130215L21Rik
    Summary
    Enables oxysterol binding activity; protein kinase A catalytic subunit binding activity; and protein sequestering activity. Involved in several processes, including regionalization; regulation of animal organ morphogenesis; and regulation of macromolecule metabolic process. Acts upstream of or within several processes, including nervous system development; positive regulation of cell population proliferation; and regionalization. Located in several cellular components, including centriole; ciliary membrane; and endoplasmic reticulum-Golgi intermediate compartment. Is active in Golgi apparatus. Is expressed in several structures, including 1st branchial arch; alimentary system; central nervous system; genitourinary system; and skeleton. Used to study medulloblastoma and pulmonary emphysema. Human ortholog(s) of this gene implicated in basal cell carcinoma; hepatocellular carcinoma; malignant pleural mesothelioma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human SMO (smoothened, frizzled class receptor). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in ovary adult (RPKM 53.2), limb E14.5 (RPKM 37.8) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Smo in Genome Data Viewer
    Location:
    6 A3.3; 6 12.36 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (29735480..29761359)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (29735497..29761366)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38780 Neighboring gene tetraspanin 33 Neighboring gene STARR-positive B cell enhancer ABC_E677 Neighboring gene predicted gene 13717 Neighboring gene STARR-seq mESC enhancer starr_15451 Neighboring gene S-adenosylhomocysteine hydrolase-like 2 Neighboring gene STARR-positive B cell enhancer mm9_chr6:29783505-29783805 Neighboring gene STARR-positive B cell enhancer mm9_chr6:29787542-29787842 Neighboring gene STARR-positive B cell enhancer mm9_chr6:29788430-29788731 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29847059-29847242 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29847325-29847478 Neighboring gene STARR-positive B cell enhancer ABC_E4816 Neighboring gene striatin interacting protein 2 Neighboring gene predicted gene, 52897

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity  
    enables cAMP-dependent protein kinase inhibitor activity  
    enables cAMP-dependent protein kinase inhibitor activity  
    enables oxysterol binding PubMed 
    enables patched binding  
    enables patched binding  
    enables patched binding  
    enables protein binding PubMed 
    enables protein kinase A catalytic subunit binding PubMed 
    enables protein sequestering activity PubMed 
    Items 1 - 25 of 112
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway  
    involved_in alpha-tubulin acetylation PubMed 
    acts_upstream_of_or_within anterior/posterior pattern specification PubMed 
    acts_upstream_of apoptotic process PubMed 
    acts_upstream_of_or_within apoptotic process PubMed 
    acts_upstream_of_or_within astrocyte activation PubMed 
    acts_upstream_of_or_within atrial septum morphogenesis PubMed 
    involved_in axon extension involved in axon guidance  
    acts_upstream_of_or_within cell development PubMed 
    acts_upstream_of_or_within cell fate specification PubMed 
    acts_upstream_of cell population proliferation PubMed 
    involved_in cellular response to cholesterol PubMed 
    involved_in central nervous system development  
    acts_upstream_of_or_within central nervous system development PubMed 
    acts_upstream_of_or_within central nervous system neuron differentiation PubMed 
    acts_upstream_of_or_within cerebellar cortex morphogenesis PubMed 
    acts_upstream_of_or_within cerebral cortex development PubMed 
    involved_in commissural neuron axon guidance  
    involved_in commissural neuron axon guidance  
    involved_in contact inhibition  
    involved_in contact inhibition  
    acts_upstream_of_or_within dentate gyrus development PubMed 
    involved_in determination of left/right asymmetry in lateral mesoderm PubMed 
    acts_upstream_of_or_within determination of left/right symmetry PubMed 
    acts_upstream_of_or_within developmental growth PubMed 
    acts_upstream_of_or_within digestive tract development PubMed 
    acts_upstream_of_or_within dopaminergic neuron differentiation PubMed 
    acts_upstream_of_or_within dorsal/ventral neural tube patterning PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation PubMed 
    acts_upstream_of_or_within embryonic organ development PubMed 
    acts_upstream_of epithelial cell differentiation PubMed 
    acts_upstream_of epithelial cell proliferation PubMed 
    acts_upstream_of_or_within epithelial-mesenchymal cell signaling PubMed 
    involved_in forebrain morphogenesis PubMed 
    acts_upstream_of_or_within gene expression PubMed 
    acts_upstream_of hair follicle development PubMed 
    acts_upstream_of_or_within hair follicle morphogenesis PubMed 
    involved_in heart looping PubMed 
    acts_upstream_of_or_within heart morphogenesis PubMed 
    acts_upstream_of_or_within homeostasis of number of cells within a tissue PubMed 
    acts_upstream_of_or_within in utero embryonic development PubMed 
    acts_upstream_of_or_within left/right axis specification PubMed 
    acts_upstream_of_or_within mammary gland epithelial cell differentiation PubMed 
    involved_in mesenchymal to epithelial transition  
    involved_in mesenchymal to epithelial transition involved in metanephric renal vesicle formation PubMed 
    involved_in midgut development PubMed 
    acts_upstream_of_or_within multicellular organism growth PubMed 
    acts_upstream_of_or_within multicellular organism growth PubMed 
    acts_upstream_of_or_within myoblast migration PubMed 
    acts_upstream_of_or_within negative regulation of DNA binding PubMed 
    involved_in negative regulation of DNA binding PubMed 
    involved_in negative regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of epithelial cell differentiation PubMed 
    involved_in negative regulation of gene expression PubMed 
    acts_upstream_of_or_within negative regulation of hair follicle development PubMed 
    involved_in negative regulation of hepatocyte proliferation  
    involved_in negative regulation of neuron apoptotic process  
    involved_in negative regulation of protein phosphorylation PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within neural crest cell migration PubMed 
    acts_upstream_of neuroblast proliferation PubMed 
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth PubMed 
    acts_upstream_of_or_within ossification PubMed 
    acts_upstream_of_or_within osteoblast differentiation PubMed 
    acts_upstream_of_or_within pancreas morphogenesis PubMed 
    involved_in pattern specification process  
    acts_upstream_of_or_within pattern specification process PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of autophagy  
    involved_in positive regulation of branching involved in ureteric bud morphogenesis PubMed 
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of cell population proliferation  
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of gene expression PubMed 
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of gene expression  
    involved_in positive regulation of hepatic stellate cell activation  
    acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation PubMed 
    involved_in positive regulation of multicellular organism growth PubMed 
    involved_in positive regulation of neural precursor cell proliferation  
    acts_upstream_of_or_within positive regulation of neuroblast proliferation PubMed 
    involved_in positive regulation of organ growth PubMed 
    acts_upstream_of_or_within positive regulation of protein import into nucleus PubMed 
    acts_upstream_of_or_within positive regulation of smoothened signaling pathway PubMed 
    acts_upstream_of positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of vascular associated smooth muscle cell migration  
    acts_upstream_of protein import into nucleus PubMed 
    acts_upstream_of_or_within protein localization to nucleus PubMed 
    acts_upstream_of_or_within protein stabilization PubMed 
    acts_upstream_of_or_within regulation of gene expression PubMed 
    involved_in regulation of heart morphogenesis PubMed 
    involved_in regulation of localization PubMed 
    acts_upstream_of_or_within regulation of somatic stem cell population maintenance PubMed 
    acts_upstream_of_or_within response to inositol PubMed 
    acts_upstream_of_or_within skeletal muscle fiber development PubMed 
    involved_in smooth muscle tissue development  
    involved_in smoothened signaling pathway  
    acts_upstream_of_or_within smoothened signaling pathway PubMed 
    acts_upstream_of_or_within smoothened signaling pathway PubMed 
    acts_upstream_of_or_within smoothened signaling pathway PubMed 
    involved_in smoothened signaling pathway PubMed 
    involved_in smoothened signaling pathway  
    involved_in somite development PubMed 
    involved_in spinal cord dorsal/ventral patterning PubMed 
    acts_upstream_of_or_within thalamus development PubMed 
    acts_upstream_of_or_within type B pancreatic cell development PubMed 
    acts_upstream_of_or_within vasculogenesis PubMed 
    involved_in ventral midline determination PubMed 
    Items 1 - 25 of 112
    Items 1 - 20 of 28
    Component Evidence Code Pubs
    located_in 9+0 non-motile cilium PubMed 
    is_active_in Golgi apparatus PubMed 
    located_in Golgi apparatus PubMed 
    colocalizes_with Golgi apparatus  
    located_in axonal growth cone  
    located_in caveola  
    colocalizes_with caveola  
    located_in centriole PubMed 
    located_in ciliary membrane PubMed 
    located_in ciliary membrane  
    is_active_in cilium  
    located_in cilium PubMed 
    is_active_in cilium PubMed 
    located_in cilium PubMed 
    located_in cytoplasm PubMed 
    is_active_in dendrite  
    located_in dendrite  
    located_in dendritic growth cone  
    located_in endocytic vesicle membrane  
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum-Golgi intermediate compartment PubMed 
    located_in intracellular membrane-bounded organelle  
    located_in late endosome PubMed 
    located_in neuronal cell body  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    Items 1 - 20 of 28

    General protein information

    Preferred Names
    protein smoothened
    Names
    bent body
    smoothened homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176996.5NP_795970.3  protein smoothened precursor

      See identical proteins and their annotated locations for NP_795970.3

      Status: VALIDATED

      Source sequence(s)
      AC069469
      Consensus CDS
      CCDS19965.1
      UniProtKB/Swiss-Prot
      P56726
      UniProtKB/TrEMBL
      Q4VBD5
      Related
      ENSMUSP00000001812.5, ENSMUST00000001812.5
      Conserved Domains (2) summary
      cd07451
      Location:70200
      CRD_SMO; Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein
      pfam01534
      Location:225554
      Frizzled; Frizzled/Smoothened family membrane region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      29735480..29761359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505106.5XP_006505169.1  protein smoothened isoform X1

      Conserved Domains (2) summary
      cd15030
      Location:90420
      7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors
      cl02447
      Location:166
      CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
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