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    Ang4 angiogenin, ribonuclease A family, member 4 [ Mus musculus (house mouse) ]

    Gene ID: 219033, updated on 4-Jan-2025

    Summary

    Official Symbol
    Ang4provided by MGI
    Official Full Name
    angiogenin, ribonuclease A family, member 4provided by MGI
    Primary source
    MGI:MGI:2656551
    See related
    Ensembl:ENSMUSG00000060615 AllianceGenome:MGI:2656551
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Raa4; Rnase5d
    Summary
    Enables RNA nuclease activity. Involved in several processes, including angiogenesis; cellular response to lipopolysaccharide; and defense response to symbiont. Acts upstream of or within antibacterial humoral response. Located in extracellular space and secretory granule. Human ortholog(s) of this gene implicated in diabetic retinopathy; myocardial infarction; neurodegenerative disease (multiple); and prostate cancer. Orthologous to human ANG (angiogenin). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in large intestine adult (RPKM 272.6), small intestine adult (RPKM 79.4) and 1 other tissue See more
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    Genomic context

    See Ang4 in Genome Data Viewer
    Location:
    14 C1; 14 26.66 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (52001349..52011047, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (51763892..51773590, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 49261 Neighboring gene eosinophil-associated, ribonuclease A family, pseudogene 3 Neighboring gene eosinophil-associated, ribonuclease A family, pseudogene 4 Neighboring gene cDNA sequence AY358078 Neighboring gene ubiquitin specific peptidase 7 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA nuclease activity  
    enables RNA nuclease activity PubMed 
    enables RNA nuclease activity  
    enables actin binding  
    enables copper ion binding  
    enables endonuclease activity  
    enables heparin binding  
    enables nucleic acid binding  
    enables peptide binding  
    enables protein homodimerization activity  
    enables signaling receptor binding  
    Items 1 - 25 of 32
    Process Evidence Code Pubs
    involved_in RNA catabolic process PubMed 
    involved_in activation of phospholipase A2 activity  
    involved_in activation of protein kinase B activity  
    involved_in angiogenesis  
    involved_in angiogenesis PubMed 
    involved_in angiogenesis  
    involved_in antibacterial humoral response  
    acts_upstream_of_or_within antibacterial humoral response PubMed 
    involved_in antibacterial humoral response  
    involved_in antifungal humoral response  
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide  
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide PubMed 
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide  
    involved_in cell migration  
    involved_in cellular response to lipopolysaccharide PubMed 
    involved_in defense response to Gram-positive bacterium  
    involved_in defense response to Gram-positive bacterium  
    acts_upstream_of_or_within defense response to bacterium PubMed 
    involved_in diacylglycerol biosynthetic process  
    involved_in innate immune response  
    involved_in innate immune response PubMed 
    involved_in innate immune response  
    involved_in negative regulation of smooth muscle cell proliferation  
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of endothelial cell proliferation  
    involved_in positive regulation of phosphorylation  
    involved_in positive regulation of protein secretion  
    involved_in rRNA transcription  
    acts_upstream_of_or_within response to bacterium PubMed 
    involved_in response to hormone  
    involved_in response to hypoxia  
    involved_in response to yeast  
    Items 1 - 25 of 32
    Component Evidence Code Pubs
    located_in actin cytoskeleton  
    part_of angiogenin-PRI complex  
    located_in basement membrane  
    located_in chromosome  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleus  
    located_in secretory granule PubMed 

    General protein information

    Preferred Names
    angiogenin-4
    Names
    ribonuclease A a4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177544.4NP_808212.2  angiogenin-4 precursor

      See identical proteins and their annotated locations for NP_808212.2

      Status: VALIDATED

      Source sequence(s)
      AK136415, AK165799
      Consensus CDS
      CCDS36911.1
      UniProtKB/Swiss-Prot
      Q3TMQ6, Q3UWE7, Q80XS4, Q80Z85
      UniProtKB/TrEMBL
      W0UUX7
      Related
      ENSMUSP00000073525.6, ENSMUST00000073860.6
      Conserved Domains (1) summary
      smart00092
      Location:25141
      RNAse_Pc; Pancreatic ribonuclease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      52001349..52011047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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