BPT1 ATP-binding cassette bilirubin transporter BPT1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: BPT1
Official Full Name: ATP-binding cassette bilirubin transporter BPT1
Primary source: SGD:S000003938
Locus tag: YLL015W
See related: AllianceGenome:SGD:S000003938; FungiDB:YLL015W; VEuPathDB:YLL015W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables bilirubin transmembrane transporter activity and cadmium ion transmembrane transporter activity. Involved in bilirubin transport; cadmium ion transport; and vacuole fusion, non-autophagic. Located in fungal-type vacuole membrane. Human ortholog(s) of this gene implicated in arterial calcification of infancy; coronary artery disease; and pseudoxanthoma elasticum. Orthologous to human ABCC6 (ATP binding cassette subfamily C member 6). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Chaperonin point mutation enhances cadmium endurance in Saccharomyces cerevisiae.
Title: Chaperonin point mutation enhances cadmium endurance in Saccharomyces cerevisiae.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables bilirubin transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables bilirubin transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cadmium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in bilirubin transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in bilirubin transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cadmium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in cadmium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in vacuole fusion, non-autophagic	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in fungal-type vacuole	IBA Inferred from Biological aspect of Ancestor more info
located_in fungal-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
located_in fungal-type vacuole membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

NP_013086.1

ABC type transmembrane transporter of MRP/CFTR family; found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p

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The following sections contain reference sequences that belong to a specific genome build. Explain