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    Synpo2 synaptopodin 2 [ Mus musculus (house mouse) ]

    Gene ID: 118449, updated on 4-Jan-2025

    Summary

    Official Symbol
    Synpo2provided by MGI
    Official Full Name
    synaptopodin 2provided by MGI
    Primary source
    MGI:MGI:2153070
    See related
    Ensembl:ENSMUSG00000050315 AllianceGenome:MGI:2153070
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Myo; 1110069I04Rik; 2310068J10Rik; 9530006G20Rik
    Summary
    Enables 14-3-3 protein binding activity and muscle alpha-actinin binding activity. Predicted to be involved in several processes, including chaperone-mediated autophagy; positive regulation of actin filament bundle assembly; and regulation of Rho-dependent protein serine/threonine kinase activity. Located in nucleus. Is expressed in genitourinary system. Orthologous to human SYNPO2 (synaptopodin 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in bladder adult (RPKM 58.2), subcutaneous fat pad adult (RPKM 12.4) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Synpo2 in Genome Data Viewer
    Location:
    3 G1; 3 53.8 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (122870168..123029817, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (123076519..123236168, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08897 Neighboring gene STARR-positive B cell enhancer ABC_E6116 Neighboring gene STARR-seq mESC enhancer starr_08899 Neighboring gene ubiquitin specific peptidase 53 Neighboring gene myozenin 2 Neighboring gene STARR-seq mESC enhancer starr_08901 Neighboring gene predicted gene, 54182 Neighboring gene STARR-seq mESC enhancer starr_08902 Neighboring gene STARR-positive B cell enhancer ABC_E10211 Neighboring gene STARR-seq mESC enhancer starr_08903 Neighboring gene STARR-seq mESC enhancer starr_08904 Neighboring gene SEC24 homolog D, COPII coat complex component Neighboring gene STARR-positive B cell enhancer mm9_chr3:123076377-123076678 Neighboring gene STARR-positive B cell enhancer mm9_chr3:123088670-123088971 Neighboring gene methyltransferase 14, N6-adenosine-methyltransferase subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

    General gene information

    Clone Names

    • MGC189849

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 14-3-3 protein binding PubMed 
    enables actin binding  
    enables actin binding PubMed 
    enables alpha-actinin binding  
    enables filamin binding  
    enables muscle alpha-actinin binding PubMed 
    enables protein binding PubMed 
    enables protein-macromolecule adaptor activity  
    Component Evidence Code Pubs
    is_active_in Z disc  
    located_in Z disc PubMed 
    located_in Z disc  
    located_in Z disc  
    is_active_in actin cytoskeleton  
    located_in actin cytoskeleton  
    located_in cytosol  
    located_in focal adhesion  
    located_in focal adhesion  
    located_in intracellular membrane-bounded organelle  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    is_active_in stress fiber  
    located_in stress fiber  
    part_of vesicle tethering complex  

    General protein information

    Preferred Names
    synaptopodin-2
    Names
    myopodin
    mypodin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001388502.1NP_001375431.1  synaptopodin-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC121315, AC121540
      UniProtKB/Swiss-Prot
      Q8C592, Q91YE8
      UniProtKB/TrEMBL
      B2RY03
      Related
      ENSMUSP00000142508.2, ENSMUST00000198584.2
      Conserved Domains (2) summary
      PHA03247
      Location:5711073
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:785
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    2. NM_001389265.1NP_001376194.1  synaptopodin-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC121540
      Conserved Domains (1) summary
      PHA03247
      Location:186688
      PHA03247; large tegument protein UL36; Provisional
    3. NM_001389266.1NP_001376195.1  synaptopodin-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC121540
      UniProtKB/TrEMBL
      A0A498WGE8
      Related
      ENSMUSP00000051570.8, ENSMUST00000051443.8
      Conserved Domains (1) summary
      PHA03247
      Location:186688
      PHA03247; large tegument protein UL36; Provisional
    4. NM_080451.2NP_536699.2  synaptopodin-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121315, AC121540
      Consensus CDS
      CCDS51063.1
      UniProtKB/TrEMBL
      B2RY03, E9Q1U2
      Related
      ENSMUSP00000102034.2, ENSMUST00000106426.8
      Conserved Domains (1) summary
      cd00992
      Location:785
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      122870168..123029817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500925.4XP_006500988.1  synaptopodin-2 isoform X1

      UniProtKB/TrEMBL
      B2RY03
      Conserved Domains (2) summary
      PHA03247
      Location:5711073
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:785
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
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