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    HLJ1 type I HSP40 co-chaperone HLJ1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855196, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HLJ1
    Official Full Name
    type I HSP40 co-chaperone HLJ1
    Primary source
    SGD:S000004771
    Locus tag
    YMR161W
    See related
    AllianceGenome:SGD:S000004771; FungiDB:YMR161W; VEuPathDB:YMR161W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ATPase activator activity. Involved in ERAD pathway. Located in endoplasmic reticulum membrane. Used to study Huntington's disease. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 1 and autosomal recessive distal hereditary motor neuronopathy 5. Orthologous to several human genes including DNAJB12 (DnaJ heat shock protein family (Hsp40) member B12). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HLJ1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (577718..578392)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Atg16p Neighboring gene Cvm1p Neighboring gene aminophospholipid-translocating P4-type ATPase DNF3 Neighboring gene Inp2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct roles for the Hsp40 and Hsp90 molecular chaperones during cystic fibrosis transmembrane conductance regulator degradation in yeast. Youker RT, et al. Mol Biol Cell, 2004 Nov. PMID 15342786, Free PMC Article
    2. The mammalian Hsp40 ERdj3 requires its Hsp70 interaction and substrate-binding properties to complement various yeast Hsp40-dependent functions. Vembar SS, et al. J Biol Chem, 2009 Nov 20. PMID 19748898, Free PMC Article
    3. Chaperone-mediated reflux of secretory proteins to the cytosol during endoplasmic reticulum stress. Igbaria A, et al. Proc Natl Acad Sci U S A, 2019 Jun 4. PMID 31101715, Free PMC Article
    4. Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein. Huyer G, et al. J Biol Chem, 2004 Sep 10. PMID 15252059
    5. COPII machinery cooperates with ER-localized Hsp40 to sequester misfolded membrane proteins into ER-associated compartments. Kakoi S, et al. Mol Biol Cell, 2013 Mar. PMID 23303252, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    type I HSP40 co-chaperone HLJ1
    NP_013884.1
    • Co-chaperone for Hsp40p; anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      577718..578392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182665.1 → NP_013884.1  TPA: type I HSP40 co-chaperone HLJ1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013884.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZY3, P48353
      UniProtKB/TrEMBL
      A6ZMM0, B3LM49, B5VPT1, C7GU61, C8ZF21, G2WKL4, N1NXG1
      Conserved Domains (1) summary
      TIGR02349
      Location:22 → 154
      DnaJ_bact; chaperone protein DnaJ
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48353.1

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