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    Vstm2a V-set and transmembrane domain containing 2A [ Mus musculus (house mouse) ]

    Gene ID: 211739, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Vstm2aprovided by MGI
    Official Full Name
    V-set and transmembrane domain containing 2Aprovided by MGI
    Primary source
    MGI:MGI:2384826
    See related
    Ensembl:ENSMUSG00000048834 AllianceGenome:MGI:2384826
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vstm2
    Summary
    Enables identical protein binding activity. Involved in several processes, including cellular response to BMP stimulus; positive regulation of brown fat cell differentiation; and positive regulation of white fat cell proliferation. Located in extracellular region. Is expressed in central nervous system; head mesenchyme; hindlimb mesenchyme; and jaw bone. Orthologous to human VSTM2A (V-set and transmembrane domain containing 2A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 13.3), frontal lobe adult (RPKM 12.1) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Vstm2a in Genome Data Viewer
    Location:
    11 A2; 11 8.89 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (16207742..16234551)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (16257742..16284551)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12010 Neighboring gene STARR-seq mESC enhancer starr_28674 Neighboring gene STARR-seq mESC enhancer starr_28675 Neighboring gene STARR-seq mESC enhancer starr_28676 Neighboring gene STARR-seq mESC enhancer starr_28677 Neighboring gene STARR-seq mESC enhancer starr_28678 Neighboring gene STARR-seq mESC enhancer starr_28679 Neighboring gene STARR-seq mESC enhancer starr_28680 Neighboring gene STARR-seq mESC enhancer starr_28681 Neighboring gene predicted gene 12011 Neighboring gene STARR-seq mESC enhancer starr_28683 Neighboring gene STARR-seq mESC enhancer starr_28684 Neighboring gene STARR-seq mESC enhancer starr_28685 Neighboring gene STARR-seq mESC enhancer starr_28687 Neighboring gene STARR-positive B cell enhancer ABC_E11470 Neighboring gene predicted gene 12012 Neighboring gene SEC61 translocon subunit gamma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Control of adipogenic commitment by a STAT3-VSTM2A axis. Al Dow M, et al. Am J Physiol Endocrinol Metab, 2021 Feb 1. PMID 33196296, Free PMC Article
    2. Amplification of Adipogenic Commitment by VSTM2A. Secco B, et al. Cell Rep, 2017 Jan 3. PMID 28052263, Free PMC Article
    3. Identification of mechanosensitive genes during skeletal development: alteration of genes associated with cytoskeletal rearrangement and cell signalling pathways. Rolfe RA, et al. BMC Genomics, 2014 Jan 20. PMID 24443808, Free PMC Article
    4. Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. Gu Z, et al. PLoS One, 2015. PMID 25826454, Free PMC Article
    5. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Control of adipogenic commitment by a STAT3-VSTM2A axis.
      Title: Control of adipogenic commitment by a STAT3-VSTM2A axis.
    2. VSTM2A is produced to preserve and amplify the adipogenic capability of adipose precursors.
      Title: Amplification of Adipogenic Commitment by VSTM2A.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC38877, 9330184N17Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to BMP stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of brown fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of brown fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of lipid storage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of white fat cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of white fat cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    V-set and transmembrane domain-containing protein 2A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290539.2 → NP_001277468.1  V-set and transmembrane domain-containing protein 2A isoform 1 precursor

      See identical proteins and their annotated locations for NP_001277468.1

      Status: VALIDATED

      Source sequence(s)
      AK033048, AK134954, AK137363, BM963943
      UniProtKB/TrEMBL
      A0A140LHB6
      Related
      ENSMUSP00000146349.2, ENSMUST00000208926.2
      Conserved Domains (2) summary
      smart00410
      Location:33 → 148
      IG_like; Immunoglobulin like
      cl11960
      Location:31 → 138
      Ig; Immunoglobulin domain

    2. NM_001363461.1 → NP_001350390.1  V-set and transmembrane domain-containing protein 2A isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL604031
      UniProtKB/TrEMBL
      A0A140LHB6
      Conserved Domains (1) summary
      smart00410
      Location:33 → 148
      IG_like; Immunoglobulin like

    3. NM_145967.3 → NP_666079.2  V-set and transmembrane domain-containing protein 2A isoform 2 precursor

      See identical proteins and their annotated locations for NP_666079.2

      Status: VALIDATED

      Source sequence(s)
      AK033048, AK134954, BC027127
      Consensus CDS
      CCDS24441.2
      UniProtKB/Swiss-Prot
      Q8R0A6
      UniProtKB/TrEMBL
      F6Y6A6
      Related
      ENSMUSP00000105272.3, ENSMUST00000109645.9
      Conserved Domains (2) summary
      smart00410
      Location:33 → 148
      IG_like; Immunoglobulin like
      pfam07686
      Location:31 → 138
      V-set; Immunoglobulin V-set domain

    RNA

    1. NR_156693.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL604031, CN530668

    2. NR_156694.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL604031

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      16207742..16234551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R0A6.2 GenPept UniProtKB/Swiss-Prot:Q8R0A6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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