Trx2 Thioredoxin 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Trx2provided by FlyBase
Official Full Name: Thioredoxin 2provided by FlyBase
Primary source: FLYBASE:FBgn0040070
Locus tag: Dmel_CG31884
See related: AllianceGenome:FB:FBgn0040070
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 31884; anon-WO0118547.188; CG31884; CG3864; DmelTrx-2; Dmel\CG31884; dmtrx-2; DmTrx-2; DTrx-2; Trx; trx-2; Trx-2; TRX2
Summary: Enables glutathione disulfide oxidoreductase activity. Involved in several processes, including cell redox homeostasis; defense response to fungus; and determination of adult lifespan. Located in nucleus. Is expressed in adult head; adult heart; imaginal disc; and primary spermatocyte. Orthologous to several human genes including TXN (thioredoxin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (9613166..9616404)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (9613166..9616404)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

This is the first demonstration of biochemical and physiological consequences caused by loss of Trx-2 in Drosophila.
Title: Loss of Trx-2 enhances oxidative stress-dependent phenotypes in Drosophila.
gene for thioredoxin (DmTrx-2) was cloned and expressed, and the protein characterized
Title: Thioredoxin-2 but not thioredoxin-1 is a substrate of thioredoxin peroxidase-1 from Drosophila melanogaster: isolation and characterization of a second thioredoxin in D. Melanogaster and evidence for distinct biological functions of Trx-1 and Trx-2.
Trx-2 affects lifespan in Drosophila. Mutants have a decreased lifespan.
Title: Thioredoxin-2 affects lifespan and oxidative stress in Drosophila.
Drosophila thioredoxin can function as an anti-aging agent and as a suppressor of Parkin-associated endothelin receptor-like receptor - and poly-glutamine-induced neurotoxicity
Title: Thioredoxin suppresses Parkin-associated endothelin receptor-like receptor-induced neurotoxicity and extends longevity in Drosophila.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables disulfide oxidoreductase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione disulfide oxidoreductase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-disulfide reductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

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