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    Zw Zwischenferment [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32974, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zwprovided by FlyBase
    Official Full Name
    Zwischenfermentprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004057
    Locus tag
    Dmel_CG12529
    See related
    AllianceGenome:FB:FBgn0004057
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12529; Dmel\CG12529; G-6-PD; G-6-pdh; G-6pd; G-6PD; G6-pd; G6-PD; g6pd; G6pd; G6PD; G6pdh; G6PDH; zw
    Summary
    Enables glucose-6-phosphate dehydrogenase activity. Involved in pentose-phosphate shunt, oxidative branch. Predicted to be active in cytosol. Is expressed in adult fat body and adult head. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cerebrovascular disease; favism; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    18D13-18D13; 1-63 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19667252..19672353)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19561285..19566386)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44512 Neighboring gene Ssu72 CTD phosphatase Neighboring gene eye transformer Neighboring gene domeless Neighboring gene Ubiquilin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of gene function: a comparison of enzyme activity levels in relation to gene dosage in diploids and triploids of Drosophila melanogaster. Lucchesi JC, et al. Biochem Genet, 1973 May. PMID 4197884
    2. Dosage Compensation in DROSOPHILA MELANOGASTER Triploids. II. Glucose-6-Phosphate Dehydrogenase Activity. Maroni G, et al. Genetics, 1973 Jun. PMID 17248620, Free PMC Article
    3. IN VIVO Function of Rare G6pd Variants from Natural Populations of DROSOPHILA MELANOGASTER. Eanes WF, et al. Genetics, 1986 Jul. PMID 17246336, Free PMC Article
    4. Coding sequence evolution. Kreitman M, et al. Curr Opin Genet Dev, 1999 Dec. PMID 10607619
    5. Amino acid polymorphism and rare electrophoretic variants of G6PD from natural populations of Drosophila melanogaster. Eanes WF, et al. Genetics, 1996 May. PMID 8722791, Free PMC Article

    See all (256) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. glucose-6-phosphate dehydrogenase overexpression extends the life span of Drosophila melanogaster
      Title: Overexpression of glucose-6-phosphate dehydrogenase extends the life span of Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucose-6-phosphate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucose-6-phosphate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucose-6-phosphate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucose-6-phosphate dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NADP metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glucose 6-phosphate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt, oxidative branch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pentose-phosphate shunt, oxidative branch IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zwischenferment
    Names
    CG12529-PA
    CG12529-PB
    CG12529-PC
    Glucose-6-phosphate DH
    Zw-PA
    Zw-PB
    Zw-PC
    glucose 6-phosphate dehydrogenase
    glucose-6-phosphate 1dehydrogenase
    glucose-6-phosphate dehydrogenase
    zwishenferment
    NP_001285456.1
    NP_523411.1
    NP_728287.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19667252..19672353
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078687.2 → NP_523411.1  zwischenferment, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523411.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7FNK0, P12646, Q27574, Q27872, Q27879, Q27881, Q9VWE2, Q9VWE3, X2JEF0
      Related
      FBpp0074517
      Conserved Domains (3) summary
      TIGR00871
      Location:35 → 498
      zwf; glucose-6-phosphate 1-dehydrogenase
      pfam00479
      Location:39 → 213
      G6PD_N; Glucose-6-phosphate dehydrogenase, NAD binding domain
      pfam02781
      Location:216 → 508
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    2. NM_167676.2 → NP_728287.1  zwischenferment, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728287.1

      Status: REVIEWED

      Related
      FBpp0074518
      Conserved Domains (3) summary
      TIGR00871
      Location:13 → 476
      zwf; glucose-6-phosphate 1-dehydrogenase
      pfam00479
      Location:17 → 191
      G6PD_N; Glucose-6-phosphate dehydrogenase, NAD binding domain
      pfam02781
      Location:194 → 486
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    3. NM_001298527.1 → NP_001285456.1  zwischenferment, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285456.1

      Status: REVIEWED

      Conserved Domains (3) summary
      TIGR00871
      Location:13 → 476
      zwf; glucose-6-phosphate 1-dehydrogenase
      pfam00479
      Location:17 → 191
      G6PD_N; Glucose-6-phosphate dehydrogenase, NAD binding domain
      pfam02781
      Location:194 → 486
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12646.2 P12646
    X2JEF0 X2JEF0

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