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    Tfb1 Transcription factor B1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36598, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tfb1provided by FlyBase
    Official Full Name
    Transcription factor B1provided by FlyBase
    Primary source
    FLYBASE:FBgn0033929
    Locus tag
    Dmel_CG8151
    See related
    AllianceGenome:FB:FBgn0033929
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8151; Dmel\CG8151; Dmp62; l(2)06949; l(2)06950; p62; TFB1; TfBl
    Summary
    Involved in response to UV. Part of transcription factor TFIIH holo complex. Is expressed in alimentary canal; larval brain; organism; pericardial cell; and testis. Orthologous to human GTF2H1 (general transcription factor IIH subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tfb1 in Genome Data Viewer
    Location:
    50F6-50F6; 2-70 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14363048..14365473)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10250553..10252978)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Activity-regulated cytoskeleton associated protein 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA polymerase II promoter clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide-excision repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in response to UV IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in transcription open complex formation at RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of transcription factor TFIIH core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIH core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIH core complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of transcription factor TFIIH holo complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIH holo complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIIH holo complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor B1
    Names
    CG8151-PA
    CG8151-PB
    CG8151-PC
    CG8151-PD
    TFB1 ortholog
    TfBl
    Tfb1-PA
    Tfb1-PB
    Tfb1-PC
    Tfb1-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14363048..14365473
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137113.4 → NP_610957.1  transcription factor B1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610957.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZH0, Q0E978, Q960E8
      UniProtKB/TrEMBL
      A0A0B4K726
      Related
      FBpp0086676
      Conserved Domains (3) summary
      smart00751
      Location:104 → 157
      BSD; domain in transcription factors and synapse-associated proteins
      cd13229
      Location:10 → 104
      PH_TFIIH; Transcription Factor II H (TFIIH) Pleckstrin homology (PH) domain
      pfam03909
      Location:181 → 234
      BSD; BSD domain

    2. NM_001259392.2 → NP_001246321.1  transcription factor B1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246321.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZH0, Q0E978, Q960E8
      UniProtKB/TrEMBL
      A0A0B4K726
      Conserved Domains (3) summary
      smart00751
      Location:104 → 157
      BSD; domain in transcription factors and synapse-associated proteins
      cd13229
      Location:10 → 104
      PH_TFIIH; Transcription Factor II H (TFIIH) Pleckstrin homology (PH) domain
      pfam03909
      Location:181 → 234
      BSD; BSD domain

    3. NM_166048.1 → NP_725382.1  transcription factor B1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725382.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZH0, Q0E978, Q960E8
      UniProtKB/TrEMBL
      A0A0B4K726
      Related
      FBpp0086678, FBtr0087550
      Conserved Domains (3) summary
      smart00751
      Location:104 → 157
      BSD; domain in transcription factors and synapse-associated proteins
      cd13229
      Location:10 → 104
      PH_TFIIH; Transcription Factor II H (TFIIH) Pleckstrin homology (PH) domain
      pfam03909
      Location:181 → 234
      BSD; BSD domain

    4. NM_166049.1 → NP_725383.1  transcription factor B1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725383.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZH0, Q0E978, Q960E8
      UniProtKB/TrEMBL
      A0A0B4K726
      Related
      FBpp0086677, FBtr0087549
      Conserved Domains (3) summary
      smart00751
      Location:104 → 157
      BSD; domain in transcription factors and synapse-associated proteins
      cd13229
      Location:10 → 104
      PH_TFIIH; Transcription Factor II H (TFIIH) Pleckstrin homology (PH) domain
      pfam03909
      Location:181 → 234
      BSD; BSD domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K726 A0A0B4K726
    Q960E8.1 Q960E8

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