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    Pax Paxillin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35215, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Paxprovided by FlyBase
    Official Full Name
    Paxillinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0041789
    Locus tag
    Dmel_CG31794
    See related
    AllianceGenome:FB:FBgn0041789
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18061; CG18576; CG31794; CT40481; CT42454; Dmel\CG31794; dPax; Dpax; DpaxA; DPaxillin; DPxn; DPXN; DPxn37; pax; pAX; PAX; PDLP; Pxn
    Summary
    Involved in several processes, including dorsal appendage formation; leg disc development; and regulation of myoblast fusion. Located in focal adhesion and muscle tendon junction. Is expressed in several structures, including follicle cell; gut section; larval somatic muscle cell; mesoderm; and visceral mesoderm derivative. Orthologous to several human genes including PXN (paxillin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pax in Genome Data Viewer
    Location:
    37D5-37D7; 2-54 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19400753..19426596, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19400753..19426596, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene small non-coding RNA 359 Neighboring gene Galactose-specific C-type lectin Neighboring gene lectin-37Da Neighboring gene lectin-37Db Neighboring gene uncharacterized protein Neighboring gene Alkaline phosphatase 12 Neighboring gene RtcB RNA ligase Neighboring gene Rab9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel muscle LIM-only protein is generated from the paxillin gene locus in Drosophila. Yagi R, et al. EMBO Rep, 2001 Sep. PMID 11520860, Free PMC Article
    2. Anteroposterior regionalization of the brain: genetic and comparative aspects. Lichtneckert R, et al. Adv Exp Med Biol, 2008. PMID 18683636
    3. Mechanochemical regulation of oscillatory follicle cell dynamics in the developing Drosophila egg chamber. Koride S, et al. Mol Biol Cell, 2014 Nov 5. PMID 24943847, Free PMC Article
    4. Epithelial rotation promotes the global alignment of contractile actin bundles during Drosophila egg chamber elongation. Cetera M, et al. Nat Commun, 2014 Nov 21. PMID 25413675, Free PMC Article
    5. Nuclear localization of the ERK MAP kinase mediated by Drosophila alphaPS2betaPS integrin and importin-7. James BP, et al. Mol Biol Cell, 2007 Oct. PMID 17699602, Free PMC Article

    See all (124) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that tramtrack69 regulates ovary epithelial tube morphogenesis through Paxillin, Dynamin, and the homeobox protein Mirror.
      Title: Following the 'tracks': Tramtrack69 regulates epithelial tube expansion in the Drosophila ovary through Paxillin, Dynamin, and the homeobox protein Mirror.
    2. New insights from hemichordate genomes: prebilaterian origin and parallel modifications in the paired domain of the Pax gene eyegone
      Title: New insights from hemichordate genomes: prebilaterian origin and parallel modifications in the paired domain of the Pax gene eyegone.
    3. Data show that Pax genes are involved in the development of the anterior/posterior brain boundary zone during embryonic CNS development in Drosophila.
      Title: Anteroposterior regionalization of the brain: genetic and comparative aspects.
    4. Results identify a link between the focal adhesion protein paxillin and the Atg1 kinase, which has been previously implicated in autophagy.
      Title: Genetic interactions between Drosophila melanogaster Atg1 and paxillin reveal a role for paxillin in autophagosome formation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in dorsal appendage formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in leg disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of autophagy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in muscle tendon junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    paxillin
    Names
    CG31794-PA
    CG31794-PB
    CG31794-PC
    CG31794-PD
    CG31794-PF
    CG31794-PG
    CG31794-PH
    CG31794-PJ
    CG31794-PK
    D-Paxillin
    Pax-PA
    Pax-PB
    Pax-PC
    Pax-PD
    Pax-PF
    Pax-PG
    Pax-PH
    Pax-PJ
    Pax-PK
    Pax-derived LIM only protein
    Paxillin-derived LIM-only protein
    paxilin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19400753..19426596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259161.3 → NP_001246090.1  paxillin, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246090.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BPQ9, Q9VIX2
      Conserved Domains (4) summary
      cd09337
      Location:407 → 458
      LIM2_Paxillin_like; The second LIM domain of the paxillin like protein family
      cd09338
      Location:466 → 518
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09411
      Location:525 → 576
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:348 → 400
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

    2. NM_165293.3 → NP_724183.1  paxillin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724183.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8INW7, Q8MQX3
      Related
      FBpp0080751
      Conserved Domains (4) summary
      cd09337
      Location:383 → 434
      LIM2_Paxillin_like; The second LIM domain of the paxillin like protein family
      cd09338
      Location:442 → 494
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09411
      Location:501 → 552
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:324 → 376
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

    3. NM_165294.3 → NP_724184.2  paxillin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724184.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2PDT4, Q8MQX3
      Conserved Domains (4) summary
      cd09337
      Location:407 → 458
      LIM2_Paxillin_like; The second LIM domain of the paxillin like protein family
      cd09338
      Location:466 → 518
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09411
      Location:525 → 576
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:348 → 400
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

    4. NM_001038824.2 → NP_001033913.1  paxillin, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033913.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2PDT4, Q8MQX3
      Conserved Domains (4) summary
      cd09337
      Location:407 → 458
      LIM2_Paxillin_like; The second LIM domain of the paxillin like protein family
      cd09338
      Location:466 → 518
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09411
      Location:525 → 576
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:348 → 400
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

    5. NM_165295.2 → NP_724185.1  paxillin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724185.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQX3, Q9VIX3
      Related
      FBpp0080753
      Conserved Domains (4) summary
      cd09337
      Location:382 → 433
      LIM2_Paxillin_like; The second LIM domain of the paxillin like protein family
      cd09338
      Location:441 → 493
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09411
      Location:500 → 551
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:323 → 375
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

    6. NM_078877.4 → NP_523601.2  paxillin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523601.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BPQ9, Q9VIX2
      Related
      FBpp0080754
      Conserved Domains (4) summary
      cd09337
      Location:407 → 458
      LIM2_Paxillin_like; The second LIM domain of the paxillin like protein family
      cd09338
      Location:466 → 518
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09411
      Location:525 → 576
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:348 → 400
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

    7. NM_001273644.1 → NP_001260573.1  paxillin, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260573.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BPQ9, Q9VIX2
      Conserved Domains (4) summary
      cd09337
      Location:407 → 458
      LIM2_Paxillin_like; The second LIM domain of the paxillin like protein family
      cd09338
      Location:466 → 518
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09411
      Location:525 → 576
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:348 → 400
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

    8. NM_001259160.1 → NP_001246089.1  paxillin, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246089.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMM0, Q8MQX3
      Conserved Domains (4) summary
      cd09337
      Location:389 → 440
      LIM2_Paxillin_like; The second LIM domain of the paxillin like protein family
      cd09338
      Location:448 → 500
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09411
      Location:507 → 558
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:330 → 382
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

    9. NM_165296.3 → NP_724186.2  paxillin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724186.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8INW6, Q966T5
      Conserved Domains (3) summary
      cd09337
      Location:81 → 132
      LIM2_Paxillin_like; The second LIM domain of the paxillin like protein family
      cd09336
      Location:22 → 74
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      cl02475
      Location:140 → 187
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3DMM0 D3DMM0
    Q2PDT4 Q2PDT4
    Q8INW7 Q8INW7
    Q8MQX3 Q8MQX3
    Q966T5 Q966T5
    Q9BPQ9 Q9BPQ9
    Q9GSE0 Q9GSE0
    Q9VIX2 Q9VIX2
    Q9VIX3 Q9VIX3

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