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    Naa20A N(alpha)-acetyltransferase 20 A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32962, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Naa20Aprovided by FlyBase
    Official Full Name
    N(alpha)-acetyltransferase 20 Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031043
    Locus tag
    Dmel_CG14222
    See related
    AllianceGenome:FB:FBgn0031043
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14222; DmAAF48987; Dmel\CG14222; dNAA20; Naa20; NAA20
    Summary
    Predicted to enable peptide alpha-N-acetyltransferase activity. Involved in negative regulation of neuron apoptotic process. Part of NatB complex. Is expressed in several structures, including embryonic/larval fat body; embryonic/larval midgut primordium; germline cell; gut section; and hindgut proper primordium. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 73. Orthologous to human NAA20 (N-alpha-acetyltransferase 20, NatB catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Naa20A in Genome Data Viewer
    Location:
    18D7-18D7; 1-63 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19621451..19623074, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19515484..19517107, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Translocase of inner membrane 9b Neighboring gene Phosphoseryl tRNA kinase Neighboring gene uncharacterized protein Neighboring gene MAPK Phosphatase 4 Neighboring gene uncharacterized protein Neighboring gene enhancer of yellow 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Maturation of NAA20 Aminoterminal End Is Essential to Assemble NatB N-Terminal Acetyltransferase Complex. Lasa M, et al. J Mol Biol, 2020 Nov 6. PMID 32976911
    2. Drosophila Psidin regulates olfactory neuron number and axon targeting through two distinct molecular mechanisms. Stephan D, et al. J Neurosci, 2012 Nov 14. PMID 23152593, Free PMC Article
    3. N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteins. Polevoda B, et al. J Mol Biol, 2003 Jan 24. PMID 12507466
    4. NatB regulates Rb mutant cell death and tumor growth by modulating EGFR/MAPK signaling through the N-end rule pathways. Sheng Z, et al. PLoS Genet, 2020 Jun. PMID 32559195, Free PMC Article
    5. Absence of N-terminal acetyltransferase diversification during evolution of eukaryotic organisms. Rathore OS, et al. Sci Rep, 2016 Feb 10. PMID 26861501, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Maturation of NAA20 Aminoterminal End Is Essential to Assemble NatB N-Terminal Acetyltransferase Complex.
      Title: Maturation of NAA20 Aminoterminal End Is Essential to Assemble NatB N-Terminal Acetyltransferase Complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide alpha-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of NatB complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NatB complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N(alpha)-acetyltransferase 20 A
    Names
    CG14222-PA
    CG14222-PB
    CG14222-PC
    CG14222-PD
    N(alpha)-acetyltransferase 20
    NAA20 ortholog
    Naa20A-PA
    Naa20A-PB
    Naa20A-PC
    Naa20A-PD
    NP_001259714.1
    NP_001259715.1
    NP_001259716.1
    NP_608331.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19621451..19623074 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272785.1 → NP_001259714.1  N(alpha)-acetyltransferase 20 A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259714.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PI14
      Conserved Domains (1) summary
      COG0456
      Location:1 → 151
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

    2. NM_134487.3 → NP_608331.1  N(alpha)-acetyltransferase 20 A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608331.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWF5
      Related
      FBpp0074532
      Conserved Domains (2) summary
      COG0456
      Location:1 → 151
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      pfam00583
      Location:51 → 126
      Acetyltransf_1; Acetyltransferase (GNAT) family

    3. NM_001272787.2 → NP_001259716.1  N(alpha)-acetyltransferase 20 A, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259716.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWF5
      Conserved Domains (2) summary
      COG0456
      Location:1 → 151
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      pfam00583
      Location:51 → 126
      Acetyltransf_1; Acetyltransferase (GNAT) family

    4. NM_001272786.1 → NP_001259715.1  N(alpha)-acetyltransferase 20 A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259715.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWF5
      Conserved Domains (2) summary
      COG0456
      Location:1 → 151
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      pfam00583
      Location:51 → 126
      Acetyltransf_1; Acetyltransferase (GNAT) family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PI14 M9PI14
    Q9VWF5 Q9VWF5

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