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    et eye transformer [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32975, updated on 9-Dec-2024

    Summary

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    Official Symbol
    etprovided by FlyBase
    Official Full Name
    eye transformerprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031055
    Locus tag
    Dmel_CG14225
    See related
    AllianceGenome:FB:FBgn0031055
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14225; Dmel\CG14225; Et; ET; lat; Lat; Latran
    Summary
    Enables STAT family protein binding activity; protein dimerization activity; and protein tyrosine kinase binding activity. Involved in defense response to bacterium and negative regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in membrane. Is expressed in medullary zone of lymph gland primary lobe. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    18D13-18D13; 1-63 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19672312..19675891, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19566345..19569924, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44512 Neighboring gene Ssu72 CTD phosphatase Neighboring gene Zwischenferment Neighboring gene domeless Neighboring gene Ubiquilin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a putative invertebrate helical cytokine similar to the ciliary neurotrophic factor/leukemia inhibitory factor family by PSI-BLAST-based approach. Cheng G, et al. J Interferon Cytokine Res, 2009 Aug. PMID 19514841
    2. JAK/STAT signaling is involved in air sac primordium development of Drosophila melanogaster. Powers N, et al. FEBS Lett, 2019 Apr. PMID 30854626
    3. Fat- and sugar-induced signals regulate sweet and fat taste perception in Drosophila. Zhao Y, et al. Cell Rep, 2023 Nov 28. PMID 37934669, Free PMC Article
    4. Rel governs loser elimination during stem cell competition in the Drosophila testis. Hof-Michel S, et al. Eur J Cell Biol, 2024 Mar. PMID 37995529
    5. Tools and methods for studying the Drosophila JAK/STAT pathway. Chen Q, et al. Methods, 2014 Jun 15. PMID 24685392

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Et/Lat is trafficked through the endocytic machinery for lysosomal degradation but at a much slower rate than Dome.
      Title: Mechanisms of JAK/STAT pathway negative regulation by the short coreceptor Eye Transformer/Latran.
    2. We show that a short type I cytokine-related receptor CG14225/Latran is required for switching off JAK/STAT signalling in prohemocytes.
      Title: A short receptor downregulates JAK/STAT signalling to control the Drosophila cellular immune response.
    3. The gene CG14225 encoded the protein Eye Transformer and was found to negatively regulate the JAK/STAT signal pathway.
      Title: Eye transformer is a negative regulator of Drosophila JAK/STAT signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c19674072-19673713 mobile_element_type = transposon:INE-1{}5633

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables STAT family protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables cytokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of receptor signaling pathway via JAK-STAT IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of receptor signaling pathway via JAK-STAT IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    eye transformer
    Names
    CG14225-PB
    CG14225-PC
    Eye transformer
    et-PB
    et-PC
    latran

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19672312..19675891 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258832.1 → NP_001245761.1  eye transformer, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245761.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NE35

    2. NM_134499.2 → NP_608343.2  eye transformer, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608343.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4XVI7, Q9VWE1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NE35 M9NE35
    Q9VWE1 Q9VWE1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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