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    Eip78C Ecdysone-induced protein 78C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40345, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Eip78Cprovided by FlyBase
    Official Full Name
    Ecdysone-induced protein 78Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004865
    Locus tag
    Dmel_CG18023
    See related
    AllianceGenome:FB:FBgn0004865
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0172774.42; anon-WO0172774.44; CG18023; dE78; Dmel\CG18023; DR-78; E78; E78A; E78B; E78D; Eip 78C; Eip78; eip78c; Eip78c; EIP78C; Eip78D; NR1E1
    Summary
    Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Is expressed in border follicle cell; main body follicle cell; nurse cell; and organism. Human ortholog(s) of this gene implicated in brain small vessel disease. Orthologous to several human genes including NR1D2 (nuclear receptor subfamily 1 group D member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Eip78C in Genome Data Viewer
    Location:
    78C2-78C3; 3-47 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21226609..21266503)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21219709..21259603)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Integrin linked kinase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45162 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila 78C early late puff contains E78, an ecdysone-inducible gene that encodes a novel member of the nuclear hormone receptor superfamily. Stone BL, et al. Cell, 1993 Oct 22. PMID 8402914
    2. DR-78, a novel Drosophila melanogaster genomic DNA fragment highly homologous to the DNA-binding domain of thyroid hormone-retinoic acid-vitamin D receptor subfamily. Martín-Blanco E, et al. Biochim Biophys Acta, 1993 Nov 16. PMID 8241283
    3. PPAR gamma activation is neuroprotective in a Drosophila model of ALS based on TDP-43. Joardar A, et al. Hum Mol Genet, 2015 Mar 15. PMID 25432537, Free PMC Article
    4. The Drosophila E78 nuclear receptor regulates dietary triglyceride uptake and systemic lipid levels. Praggastis SA, et al. Dev Dyn, 2021 May. PMID 33368768, Free PMC Article
    5. The induction of DNA puff BhC4-1 gene is a late response to the increase in 20-hydroxyecdysone titers in last instar dipteran larvae. Basso LR Jr, et al. Mech Dev, 2002 Jan. PMID 11744365

    See all (124) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Drosophila E78 nuclear receptor regulates dietary triglyceride uptake and systemic lipid levels.
      Title: The Drosophila E78 nuclear receptor regulates dietary triglyceride uptake and systemic lipid levels.
    2. Ecdysone response gene E78 controls ovarian germline stem cell niche formation and follicle survival in Drosophila.
      Title: Ecdysone response gene E78 controls ovarian germline stem cell niche formation and follicle survival in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 21243800-21251305 mobile_element_type = transposon:412{}1075
    • Loc: 21243865-21251304 mobile_element_type = transposon:412{}922

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ecdysone-induced protein 78C
    Names
    CG18023-PA
    CG18023-PB
    CG18023-PD
    CG18023-PE
    Eip78C-PA
    Eip78C-PB
    Eip78C-PD
    Eip78C-PE
    ecdysone induced protein 78C
    nuclear hormone receptor
    NP_730609.3
    • non-AUG (CUG) translation initiation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21226609..21266503
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259933.1 → NP_001246862.1  Ecdysone-induced protein 78C, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246862.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18395, O18396, P45447, Q7KTW8, Q8IPT7, Q9NBW8, Q9NBW9, Q9VP64
      UniProtKB/TrEMBL
      M9NDE9
      Conserved Domains (2) summary
      cd06941
      Location:659 → 854
      NR_LBD_DmE78_like; The ligand binding domain of Drosophila ecdysone-induced protein 78, a member of the nuclear receptor superfamily
      cd07165
      Location:363 → 443
      NR_DBD_DmE78_like; DNA-binding domain of Drosophila ecdysone-induced protein 78 (E78) like is composed of two C4-type zinc fingers

    2. NM_001259934.1 → NP_001246863.1  Ecdysone-induced protein 78C, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246863.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18395, O18396, P45447, Q7KTW8, Q8IPT7, Q9NBW8, Q9NBW9, Q9VP64
      UniProtKB/TrEMBL
      M9NDE9
      Conserved Domains (2) summary
      cd06941
      Location:659 → 854
      NR_LBD_DmE78_like; The ligand binding domain of Drosophila ecdysone-induced protein 78, a member of the nuclear receptor superfamily
      cd07165
      Location:363 → 443
      NR_DBD_DmE78_like; DNA-binding domain of Drosophila ecdysone-induced protein 78 (E78) like is composed of two C4-type zinc fingers

    3. NM_079471.3 → NP_524195.2  Ecdysone-induced protein 78C, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524195.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18395, O18396, P45447, Q7KTW8, Q8IPT7, Q9NBW8, Q9NBW9, Q9VP64
      UniProtKB/TrEMBL
      M9NDE9
      Related
      FBpp0077963
      Conserved Domains (2) summary
      cd06941
      Location:659 → 854
      NR_LBD_DmE78_like; The ligand binding domain of Drosophila ecdysone-induced protein 78, a member of the nuclear receptor superfamily
      cd07165
      Location:363 → 443
      NR_DBD_DmE78_like; DNA-binding domain of Drosophila ecdysone-induced protein 78 (E78) like is composed of two C4-type zinc fingers

    4. NM_168892.3 → NP_730609.3  Ecdysone-induced protein 78C, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730609.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P45447
      Related
      FBpp0077964
      Conserved Domains (1) summary
      cd06941
      Location:189 → 384
      NR_LBD_DmE78_like; The ligand binding domain of Drosophila ecdysone-induced protein 78, a member of the nuclear receptor superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NDE9 M9NDE9
    P45447.4 P45447

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