FRE2 ferric/cupric-chelate reductase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: FRE2
Official Full Name: ferric/cupric-chelate reductase
Primary source: SGD:S000001703
Locus tag: YKL220C
See related: AllianceGenome:SGD:S000001703; FungiDB:YKL220C; VEuPathDB:YKL220C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ferric-chelate reductase activity. Involved in copper ion import; iron ion transport; and nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See FRE2 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (9091..11226, complement)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study found that FRE2 mRNAs are regulated by the nonsense-mediated mRNA decay (NMD) under non-inducing conditions and that the FRE2 3'-UTR contributes to the degradation of the mRNAs by NMD.
Title: Nonsense-mediated mRNA decay of the ferric and cupric reductase mRNAs FRE1 and FRE2 in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ferric-chelate reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables ferric-chelate reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ferric-chelate reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables ferric-chelate reductase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in copper ion import	IBA Inferred from Biological aspect of Ancestor more info
involved_in copper ion import	IDA Inferred from Direct Assay more info	PubMed
involved_in copper ion transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular iron ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in iron ion transport	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in fungal-type vacuole	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ferric/cupric-chelate reductase

NP_012702.1

EC 1.16.1.9

Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

9091..11226 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179785.1 → NP_012702.1 TPA: ferric/cupric-chelate reductase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012702.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWY3, P36033

UniProtKB/TrEMBL

B3LQN9, B5VLU5, G2WHH4, N1P892

Conserved Domains (3) summary

cd06186
Location:435 → 605

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam08030
Location:537 → 691

NAD_binding_6; Ferric reductase NAD binding domain

pfam01794
Location:283 → 396

Ferric_reduct; Ferric reductase like transmembrane component