STUB1 STIP1 homology and U-box containing protein 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: STUB1provided by FlyBase
Official Full Name: STIP1 homology and U-box containing protein 1provided by FlyBase
Primary source: FLYBASE:FBgn0027052
Locus tag: Dmel_CG5203
See related: AllianceGenome:FB:FBgn0027052
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5203; Chip; CHIP; dCHIP; Dmel\CG5203; Stub1
Summary: Enables ubiquitin protein ligase activity. Involved in negative regulation of insulin receptor signaling pathway; positive regulation of proteolysis; and protein ubiquitination. Predicted to be active in Z disc. Is expressed in adult head; eye; and organism. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 16 and cerebellar ataxia type 48. Orthologous to human STUB1 (STIP1 homology and U-box containing protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 31E2-31E2; 2-42 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10437548..10439240)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10437548..10439240)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Taken together, our findings identified Chip as a novel partner of dLmx1a to alter cell differentiation in Drosophila eye through repressing eya and stg expression
Title: Drosophila eye developmental defect caused by elevation of the activity of the LIM-homeodomain protein, Lmx1a, requires its association with the Co-activator Chip.
study reveals that Chip is a novel interacting partner of Notch
Title: Chip physically interacts with Notch and their stoichiometry is critical for Notch function in wing development and cell proliferation in Drosophila.
Data have found that the transcriptional co-factor Chip is required for cells at the ventral eye-antennal disc border to take on a head cuticle fat
Title: The transcriptional co-factor Chip acts with LIM-homeodomain proteins to set the boundary of the eye field in Drosophila.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables Hsp70 protein binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables Hsp90 protein binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables TPR domain binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to misfolded protein	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein quality control for misfolded or incompletely synthesized proteins	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of glucocorticoid metabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: STIP1 homology and U-box containing protein 1

Names: CG5203-PA; CHIP; CHIP ortholog; NM 058093.3; STUB1-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

10437548..10439240

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058093.4 → NP_477441.1 STIP1 homology and U-box containing protein 1 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477441.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9XYW6

Related

FBpp0079617

Conserved Domains (4) summary

smart00028
Location:17 → 47

TPR; Tetratricopeptide repeats

pfam04564
Location:213 → 285

U-box; U-box domain

sd00006
Location:17 → 42

TPR; TPR repeat [structural motif]

pfam13414
Location:17 → 78

TPR_11; TPR repeat