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    dnc dunce [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31309, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dncprovided by FlyBase
    Official Full Name
    dunceprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000479
    Locus tag
    Dmel_CG32498
    See related
    AllianceGenome:FB:FBgn0000479
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10791; CG10792; CG10797; CG14267; CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3; EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII
    Summary
    Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Involved in several processes, including axon extension; learning or memory; and thermosensory behavior. Located in cytosol and nucleus. Is expressed in several structures, including Kenyon cell; gland; mushroom body; synaptic neuropil domain; and synaptic neuropil subdomain. Human ortholog(s) of this gene implicated in acrodysostosis and alcohol dependence. Orthologous to several human genes including PDE4B (phosphodiesterase 4B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dnc in Genome Data Viewer
    Location:
    3C9-3D1; 1-2 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (3176440..3343767)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (3070473..3237800)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Follicle cell protein 3C Neighboring gene uncharacterized protein Neighboring gene new glue 2 Neighboring gene new glue 3 Neighboring gene new glue 1 Neighboring gene Pre-intermoult gene 1 Neighboring gene new glue 4 Neighboring gene Salivary gland secretion 4 Neighboring gene long non-coding RNA:CR44886 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46243 Neighboring gene long non-coding RNA:CR44999 Neighboring gene uncharacterized protein Neighboring gene Myc

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Defective cyclic adenosine 3':5'-monophosphate phosphodiesterase in the Drosophila memory mutant dunce. Kauvar LM. J Neurosci, 1982 Oct. PMID 6288893, Free PMC Article
    2. Copia RNA levels are elevated in dunce mutants and modulated by cAMP. Yun YD, et al. Nucleic Acids Res, 1989 Oct 25. PMID 2478960, Free PMC Article
    3. Ca2(+)-dependent proteolytic modification of the cAMP-dependent protein kinase in Drosophila wild-type and dunce memory mutants. Müller U, et al. J Neurogenet, 1989 Nov. PMID 2560483
    4. Altered autophosphorylation of adenosine 3',5'-phosphate-dependent protein kinase in the dunce memory mutant of Drosophila melanogaster. Dévay P, et al. Neuroscience, 1986 May. PMID 3016598
    5. Molecular analysis of cDNA clones and the corresponding genomic coding sequences of the Drosophila dunce+ gene, the structural gene for cAMP phosphodiesterase. Chen CN, et al. Proc Natl Acad Sci U S A, 1986 Dec. PMID 3025834, Free PMC Article

    See all (465) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dunce activity in serotonergic neurons acts as a long-term memory checkpoint.
      Title: Dunce Phosphodiesterase Acts as a Checkpoint for Drosophila Long-Term Memory in a Pair of Serotonergic Neurons.
    2. Hangover acts as a nuclear RNA binding protein and we identified the phosphodiesterase 4d ortholog dunce as a target RNA.
      Title: Hangover Links Nuclear RNA Signaling to cAMP Regulation via the Phosphodiesterase 4d Ortholog dunce.
    3. dunce knockdown in the mushroom body neurons impairs memory without significantly affecting acquisition.
      Title: Identification of genes that promote or inhibit olfactory memory formation in Drosophila.
    4. Dunce phosphodiesterase plays a major role in the spatial regulation of cAMP dynamics.
      Title: PKA dynamics in a Drosophila learning center: coincidence detection by rutabaga adenylyl cyclase and spatial regulation by dunce phosphodiesterase.
    5. flies responding to visual novelty revealed attention-like processes with stereotypical temporal properties; these processes were modulated by genes involved in short-term memory formation, namely dunce and rutabaga
      Title: Attention-like processes in Drosophila require short-term memory genes.
    6. These results indicate that calcium influx through acetylcholine receptors is increased in dunce and that calcium extrusion to the outside and/or calcium buffering are enhanced in dunce.
      Title: Increased calcium influx through acetylcholine receptors in dunce neurons.
    7. Choice behavior in Drosophila involves central nervous learning and memory operating via cyclic AMP signaling pathways
      Title: Cyclic AMP-dependent memory mutants are defective in the food choice behavior of Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 3178521-3186128 mobile_element_type = transposon:opus{}33

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anesthesia-resistant memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in associative learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in circadian rhythm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in conditioned taste aversion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in courtship behavior TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mating behavior TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in medium-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nonassociative learning TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in olfactory learning TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in short-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thermosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dunce
    Names
    CG32498-PA
    CG32498-PB
    CG32498-PC
    CG32498-PD
    CG32498-PE
    CG32498-PF
    CG32498-PG
    CG32498-PI
    CG32498-PJ
    CG32498-PL
    CG32498-PN
    CG32498-PP
    CG32498-PQ
    CG32498-PR
    CG32498-PS
    CG32498-PT
    CG32498-PU
    dnc-PA
    dnc-PB
    dnc-PC
    dnc-PD
    dnc-PE
    dnc-PF
    dnc-PG
    dnc-PI
    dnc-PJ
    dnc-PL
    dnc-PN
    dnc-PP
    dnc-PQ
    dnc-PR
    dnc-PS
    dnc-PT
    dnc-PU
    dunce phosphodiesterase
    phosphodiesterase
    NP_001259201.1
    NP_001259202.1
    NP_001259203.1
    NP_525061.2
    NP_726846.1
    NP_726847.2
    NP_726849.1
    NP_726850.1
    NP_726851.3
    NP_726852.2
    NP_726853.2
    NP_726854.2
    NP_726855.1
    NP_726856.1
    NP_726857.1
    NP_726858.2
    NP_726859.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      3176440..3343767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166959.2 → NP_726846.1  dunce, isoform S [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726846.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W4T4
      UniProtKB/TrEMBL
      H8F4P8, Q8MS17
      Related
      FBpp0305507
      Conserved Domains (1) summary
      pfam00233
      Location:870 → 1111
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    2. NM_001272274.1 → NP_001259203.1  dunce, isoform U [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259203.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPC1
      Conserved Domains (1) summary
      pfam00233
      Location:376 → 617
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    3. NM_166963.2 → NP_726851.3  dunce, isoform T [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726851.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPC1
      Conserved Domains (1) summary
      pfam00233
      Location:376 → 617
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    4. NM_166960.3 → NP_726847.2  dunce, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726847.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W4T4
      UniProtKB/TrEMBL
      H8F4P8, Q8MS17
      Related
      FBpp0070485
      Conserved Domains (1) summary
      pfam00233
      Location:870 → 1111
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    5. NM_001272272.1 → NP_001259201.1  dunce, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259201.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPC1, M9PDN2
      Conserved Domains (1) summary
      pfam00233
      Location:303 → 544
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    6. NM_166968.3 → NP_726856.1  dunce, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726856.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IRU5, Q9W4S9
      UniProtKB/TrEMBL
      D0IQA0
      Related
      FBpp0070495
      Conserved Domains (1) summary
      pfam00233
      Location:644 → 885
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    7. NM_166961.2 → NP_726849.1  dunce, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726849.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9PGD1, M9PGX1, O76918, P12252, Q8IRU3, Q8IRU6, Q8IRU8, Q8IRV0, Q8MRN3, Q8T8M0, Q9NF62, Q9W4S8, Q9W4T0, Q9W4T1
      UniProtKB/TrEMBL
      E2QD73
      Related
      FBpp0070487
      Conserved Domains (1) summary
      pfam00233
      Location:731 → 972
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    8. NM_166964.2 → NP_726852.2  dunce, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726852.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P12252
      Related
      FBpp0070491
      Conserved Domains (1) summary
      pfam00233
      Location:729 → 970
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    9. NM_166965.2 → NP_726853.2  dunce, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726853.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9PGD1, M9PGX1, O76918, P12252, Q8IRU3, Q8IRU6, Q8IRU8, Q8IRV0, Q8MRN3, Q8T8M0, Q9NF62, Q9W4S8, Q9W4T0, Q9W4T1
      UniProtKB/TrEMBL
      E2QD73
      Related
      FBpp0070489
      Conserved Domains (1) summary
      pfam00233
      Location:731 → 972
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    10. NM_166962.2 → NP_726850.1  dunce, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726850.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P12252
      Related
      FBpp0070488
      Conserved Domains (1) summary
      pfam00233
      Location:718 → 959
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    11. NM_001272273.1 → NP_001259202.1  dunce, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259202.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPC1
      Conserved Domains (1) summary
      pfam00233
      Location:364 → 605
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    12. NM_166966.3 → NP_726854.2  dunce, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726854.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPC1
      Conserved Domains (1) summary
      pfam00233
      Location:364 → 605
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    13. NM_166967.2 → NP_726855.1  dunce, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726855.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPC1
      Related
      FBpp0070493
      Conserved Domains (1) summary
      pfam00233
      Location:362 → 603
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    14. NM_166969.2 → NP_726857.1  dunce, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726857.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPC1, M9PDN2
      Related
      FBpp0070494
      Conserved Domains (1) summary
      pfam00233
      Location:303 → 544
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    15. NM_166970.2 → NP_726858.2  dunce, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726858.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQA0
      Related
      FBpp0070496
      Conserved Domains (1) summary
      pfam00233
      Location:475 → 716
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    16. NM_080322.3 → NP_525061.2  dunce, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525061.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IRU4
      UniProtKB/TrEMBL
      C9QPC1
      Related
      FBpp0070497
      Conserved Domains (1) summary
      pfam00233
      Location:323 → 564
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    17. NM_166971.2 → NP_726859.2  dunce, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726859.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P12252
      Related
      FBpp0070498
      Conserved Domains (1) summary
      pfam00233
      Location:182 → 423
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E2QD73 E2QD73
    H8F4P8 H8F4P8
    M9PDN2 M9PDN2
    P12252.4 P12252
    Q8IRU4.1 Q8IRU4
    Q8MS17 Q8MS17
    Q9W4S9.2 Q9W4S9
    Q9W4T4.2 Q9W4T4

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