U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG6847 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32778, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG6847provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030884
    Locus tag
    Dmel_CG6847
    See related
    AllianceGenome:FB:FBgn0030884
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG6847
    Summary
    Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Is expressed in several structures, including embryonic anal pad; epithelium; gut section; sense organ; and tracheal branch primordium. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG6847 in Genome Data Viewer
    Location:
    16F3-16F3; 1-59 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17911462..17924163)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17805495..17818196)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Vacuolar protein sorting 4 Neighboring gene Shaker Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Disruption of Vps4 and JNK function in Drosophila causes tumour growth. Rodahl LM, et al. PLoS One, 2009. PMID 19194501, Free PMC Article
    2. MidExDB: a database of Drosophila CNS midline cell gene expression. Wheeler SR, et al. BMC Dev Biol, 2009 Nov 10. PMID 19903351, Free PMC Article
    3. Comparative and functional genomics of lipases in holometabolous insects. Horne I, et al. Insect Biochem Mol Biol, 2009 Aug. PMID 19540341
    4. Gene expression profiling of Drosophila tracheal fusion cells. Chandran RR, et al. Gene Expr Patterns, 2014 Jul. PMID 24928808
    5. Trachealess (Trh) regulates all tracheal genes during Drosophila embryogenesis. Chung S, et al. Dev Biol, 2011 Dec 1. PMID 21963537, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG6847-PA
    CG6847-PB
    NP_001285397.1
    NP_573259.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17911462..17924163
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298468.1 → NP_001285397.1  uncharacterized protein Dmel_CG6847, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285397.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U1C3, Q9VX01
      Conserved Domains (2) summary
      cd00707
      Location:185 → 459
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
      pfam00151
      Location:70 → 463
      Lipase; Lipase

    2. NM_133031.2 → NP_573259.2  uncharacterized protein Dmel_CG6847, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573259.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U1C3, Q9VX01
      Related
      FBpp0074279
      Conserved Domains (2) summary
      cd00707
      Location:185 → 459
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
      pfam00151
      Location:70 → 463
      Lipase; Lipase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U1C3 Q5U1C3
    Q9VX01 Q9VX01

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous