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    mEFG1 mitochondrial translation elongation factor G 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34004, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mEFG1provided by FlyBase
    Official Full Name
    mitochondrial translation elongation factor G 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0263133
    Locus tag
    Dmel_CG4567
    See related
    AllianceGenome:FB:FBgn0263133
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    B; CG4567; dEF-G1; Dmel\CG4567; G; GFM1; ico; l(2)27Cb; l(2)27Ea
    Summary
    Predicted to enable GTPase activity and translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation. Located in mitochondrion and nucleus. Is expressed in several structures, including embryonic/larval midgut primordium; gut section; larval muscle cell; mesoderm; and visceral muscle primordium. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 1. Orthologous to human GFM1 (G elongation factor mitochondrial 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mEFG1 in Genome Data Viewer
    Location:
    27E5-27E5; 2-25 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7220369..7223081, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7220369..7223081, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44989 Neighboring gene Na[+]-driven anion exchanger 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila mitochondrial translation elongation factor G1 contains a nuclear localization signal and inhibits growth and DPP signaling. Trivigno C, et al. PLoS One, 2011 Feb 25. PMID 21364917, Free PMC Article
    2. Ndae1 expression and regulation in Drosophila embryos. Tevy MF, et al. PLoS One, 2014. PMID 24676142, Free PMC Article
    3. Distinct mitogenic and cell fate specification functions of wingless in different regions of the wing. Neumann CJ, et al. Development, 1996 Jun. PMID 8674417
    4. Comparison of inter- and intraspecies variation in humans and fruit flies. Shih J, et al. Genom Data, 2015 Mar. PMID 26484147, Free PMC Article
    5. Genetic analysis of the adenosine3 (Gart) region of the second chromosome of Drosophila melanogaster. Tiong SY, et al. Genetics, 1990 Apr. PMID 2108904, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Drosophila mitochondrial translation elongation factor G1 contains a nuclear localization signal and inhibits growth and DPP signaling.
      Title: The Drosophila mitochondrial translation elongation factor G1 contains a nuclear localization signal and inhibits growth and DPP signaling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translational elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial translation elongation factor G 1
    Names
    CG4567-PA
    complementation group B
    complementation group G
    iconoclast
    lethal (2) 27Cb
    lethal (2) 27Ea
    mEFG1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7220369..7223081 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135261.2 → NP_609105.1  mitochondrial translation elongation factor G 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609105.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q494L3, Q9VM33
      Related
      FBpp0079041
      Conserved Domains (6) summary
      cd01886
      Location:44 → 316
      EF-G; Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis
      PRK12740
      Location:48 → 727
      PRK12740; elongation factor G; Reviewed
      cd01434
      Location:519 → 636
      EFG_mtEFG1_IV; EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2 ...
      cd04097
      Location:641 → 718
      mtEFG1_C; mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating ...
      cd04091
      Location:347 → 427
      mtEFG1_II_like; Domain II of mitochondrial elongation factor G1-like proteins found in eukaryotes
      cd16262
      Location:441 → 516
      EFG_III; Domain III of Elongation Factor G (EFG)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VM33.2 Q9VM33

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