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    Prosalpha6T Proteasome alpha6 subunit, Testis-specific [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34726, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prosalpha6Tprovided by FlyBase
    Official Full Name
    Proteasome alpha6 subunit, Testis-specificprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032492
    Locus tag
    Dmel_CG5648
    See related
    AllianceGenome:FB:FBgn0032492
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    5648; alpha6T; Alpha6T; CG5648; Dmel\CG5648; prosalpha6T
    Summary
    Involved in sperm individualization and spermatid nucleus elongation. Located in cytosol and male germ cell nucleus. Is expressed in male germline cell; spermatid cyst; and testis. Orthologous to human PSMA1 (proteasome 20S subunit alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Prosalpha6T in Genome Data Viewer
    Location:
    34A11-34A11; 2-47 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13232039..13233058)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13232039..13233058)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mabiki Neighboring gene Juvenile hormone binding protein 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Usp14 is required for spermatogenesis and ubiquitin stress responses in Drosophila melanogaster. Kovács L, et al. J Cell Sci, 2020 Jan 23. PMID 31974276
    2. Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the PINK1/PARKIN pathway in vivo. Yun J, et al. J Neurosci, 2008 Dec 31. PMID 19118185, Free PMC Article
    3. Circular RNAs from BOULE play conserved roles in protection against stress-induced fertility decline. Gao L, et al. Sci Adv, 2020 Nov. PMID 33177084, Free PMC Article
    4. The testis-specific proteasome subunit Prosalpha6T of D. melanogaster is required for individualization and nuclear maturation during spermatogenesis. Zhong L, et al. Development, 2007 Oct. PMID 17728345
    5. Importin-9 regulates chromosome segregation and packaging in Drosophila germ cells. Palacios V, et al. J Cell Sci, 2021 Apr 1. PMID 33632744, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium HMP PubMed 
    involved_in negative regulation of innate immune response HMP PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid nucleus elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    proteasome alpha6 subunit, Testis-specific
    Names
    CG5648-PA
    Prosalpha6T-PA
    proteasome alpha6T subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13232039..13233058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135779.3 → NP_609623.1  proteasome alpha6 subunit, Testis-specific [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609623.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VK14
      Related
      FBpp0080028
      Conserved Domains (2) summary
      COG0638
      Location:4 → 233
      PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
      cd03749
      Location:6 → 215
      proteasome_alpha_type_1; proteasome_alpha_type_1. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VK14 Q9VK14

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