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    Damm Death associated molecule related to Mch2 caspase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36266, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dammprovided by FlyBase
    Official Full Name
    Death associated molecule related to Mch2 caspaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033659
    Locus tag
    Dmel_CG18188
    See related
    AllianceGenome:FB:FBgn0033659
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18188; damm; DAMM; Damm/Daydream; Daydream; Dmel\CG18188
    Summary
    Enables cysteine-type endopeptidase activity. Involved in apoptotic process and proteolysis. Predicted to be active in cytoplasm. Is expressed in several structures, including embryonic/larval salivary gland; female germline cell; ganglia; gut section; and presumptive embryonic salivary gland. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Damm in Genome Data Viewer
    Location:
    48C5-48C5; 2-65 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11864112..11866383, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7752681..7753888, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Tweedlebeta Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. STRICA, a novel Drosophila melanogaster caspase with an unusual serine/threonine-rich prodomain, interacts with DIAP1 and DIAP2. Doumanis J, et al. Cell Death Differ, 2001 Apr. PMID 11550090
    2. Interactions of DNR1 with the apoptotic machinery of Drosophila melanogaster. Primrose DA, et al. J Cell Sci, 2007 Apr 1. PMID 17341581
    3. Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis. Lee G, et al. J Comp Neurol, 2011 Jan 1. PMID 21120926
    4. Nerve-racking - apoptotic and non-apoptotic roles of caspases in the nervous system of Drosophila. Melzer J, et al. Eur J Neurosci, 2016 Jul. PMID 26900934
    5. The cleaved-Caspase-3 antibody is a marker of Caspase-9-like DRONC activity in Drosophila. Fan Y, et al. Cell Death Differ, 2010 Mar. PMID 19960024, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    death associated molecule related to Mch2 caspase
    Names
    CG18188-PA
    CG18188-PB
    Damm-PA
    Damm-PB
    daydream
    death associated molecule related to Mch2
    NP_001303345.1
    NP_523703.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11864112..11866383 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316416.1 → NP_001303345.1  death associated molecule related to Mch2 caspase, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KHI6, Q9NBW3
      Conserved Domains (1) summary
      pfam00656
      Location:42 → 248
      Peptidase_C14; Caspase domain

    2. NM_078979.3 → NP_523703.2  death associated molecule related to Mch2 caspase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523703.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KHI6, Q9NBW3
      Related
      FBpp0087167
      Conserved Domains (1) summary
      pfam00656
      Location:42 → 248
      Peptidase_C14; Caspase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KHI6 Q7KHI6
    Q9NBW3 Q9NBW3

    Gene LinkOut

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