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    MetRS Methionyl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37177, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MetRSprovided by FlyBase
    Official Full Name
    Methionyl-tRNA synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034401
    Locus tag
    Dmel_CG15100
    See related
    AllianceGenome:FB:FBgn0034401
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-2.15; CG15100; clone 2.15; Dmel\CG15100; dMetRS; MRS; p120
    Summary
    Predicted to enable methionine-tRNA ligase activity. Predicted to be involved in methionyl-tRNA aminoacylation. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2U; hereditary spastic paraplegia 70; and trichothiodystrophy. Orthologous to human MARS1 (methionyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MetRS in Genome Data Viewer
    Location:
    55F7-55F7; 2-86 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18846858..18850599, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14734363..14738104, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46485 Neighboring gene uncharacterized protein Neighboring gene Juvenile hormone epoxide hydrolase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases. Niehues S, et al. Nat Commun, 2015 Jul 3. PMID 26138142, Free PMC Article
    2. Cell-selective labelling of proteomes in Drosophila melanogaster. Erdmann I, et al. Nat Commun, 2015 Jul 3. PMID 26138272, Free PMC Article
    3. The Zinc-BED Transcription Factor Bedwarfed Promotes Proportional Dendritic Growth and Branching through Transcriptional and Translational Regulation in Drosophila. Bhattacharjee S, et al. Int J Mol Sci, 2023 Mar 28. PMID 37047316, Free PMC Article
    4. The multienzyme complex containing nine aminoacyl-tRNA synthetases is ubiquitous from Drosophila to mammals. Kerjan P, et al. Biochim Biophys Acta, 1994 Apr 21. PMID 8161568
    5. Methionyl-tRNA Synthetase Regulates Lifespan in Drosophila. Suh YS, et al. Mol Cells, 2020 Mar 31. PMID 31940717, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methionine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionine-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables methionine-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methionyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methionyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methionyl-tRNA aminoacylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in methionyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of aminoacyl-tRNA synthetase multienzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Methionyl-tRNA synthetase
    Names
    CG15100-PA
    MetRS-PA
    NP_611382.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18846858..18850599 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137538.2 → NP_611382.1  Methionyl-tRNA synthetase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611382.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBE9, Q8MRS4
      Related
      FBpp0085809
      Conserved Domains (7) summary
      cd07957
      Location:634 → 763
      Anticodon_Ia_Met; Anticodon-binding domain of methionyl tRNA synthetases
      cd00814
      Location:255 → 625
      MetRS_core; catalytic core domain of methioninyl-tRNA synthetases
      COG0625
      Location:1 → 175
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      PRK12268
      Location:254 → 812
      PRK12268; methionyl-tRNA synthetase; Reviewed
      cd00570
      Location:1 → 65
      GST_N_family; Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic ...
      cd00939
      Location:895 → 938
      MetRS_RNA; MetRS_RNA binding domain. This short RNA-binding domain is found at the C-terminus of MetRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is repeated in Drosophila MetRS. This domain consists of a helix-turn-helix structure, which is ...
      cl02776
      Location:63 → 164
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZBE9 A1ZBE9
    Q8MRS4 Q8MRS4

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