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    CG33523 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38668, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG33523provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0053523
    Locus tag
    Dmel_CG33523
    See related
    AllianceGenome:FB:FBgn0053523
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH09028; CG10727; CG10977; CG32410; Dmel\CG33523; dVAP-B; Vap-33B
    Summary
    Located in endomembrane system. Is expressed in adult head and spermatozoon. Orthologous to human MOSPD2 (motile sperm domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG33523 in Genome Data Viewer
    Location:
    64F5-65A1; 3-16 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5923862..5930120)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5916962..5923220)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45167 Neighboring gene P[[i]]-sensitive XPR1 orthologue Neighboring gene uncharacterized protein Neighboring gene Regulator of chromosome condensation 1 Neighboring gene EGFR adaptor protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RDGBα localization and function at membrane contact sites is regulated by FFAT-VAP interactions. Yadav S, et al. J Cell Sci, 2018 Jan 8. PMID 29180517, Free PMC Article
    2. hVAPB, the causative gene of a heterogeneous group of motor neuron diseases in humans, is functionally interchangeable with its Drosophila homologue DVAP-33A at the neuromuscular junction. Chai A, et al. Hum Mol Genet, 2008 Jan 15. PMID 17947296, Free PMC Article
    3. Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner. Pennetta G, et al. Neuron, 2002 Jul 18. PMID 12160747
    4. Quantitative genomics of locomotor behavior in Drosophila melanogaster. Jordan KW, et al. Genome Biol, 2007. PMID 17708775, Free PMC Article
    5. Topological organisation of the phosphatidylinositol 4,5-bisphosphate-phospholipase C resynthesis cycle: PITPs bridge the ER-PM gap. Cockcroft S, et al. Biochem J, 2016 Dec 1. PMID 27888240

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum-endosome membrane contact site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG33523-PA
    CG33523-PB
    CG33523-PC
    CG33523-PD
    CG33523-PE
    CG33523-PF
    MSP protein
    VAMP-associated protein of 33kDa ortholog B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5923862..5930120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259713.3 → NP_001246642.1  uncharacterized protein Dmel_CG33523, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246642.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NF21
      Conserved Domains (1) summary
      pfam00650
      Location:94 → 234
      CRAL_TRIO; CRAL/TRIO domain

    2. NM_001014569.4 → NP_001014569.1  uncharacterized protein Dmel_CG33523, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014569.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I0DHK9, Q8I935
      Conserved Domains (2) summary
      pfam00635
      Location:293 → 396
      Motile_Sperm; MSP (Major sperm protein) domain
      pfam00650
      Location:94 → 234
      CRAL_TRIO; CRAL/TRIO domain

    3. NM_001274528.2 → NP_001261457.1  uncharacterized protein Dmel_CG33523, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261457.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBR6
      Conserved Domains (2) summary
      pfam00635
      Location:293 → 396
      Motile_Sperm; MSP (Major sperm protein) domain
      pfam00650
      Location:94 → 234
      CRAL_TRIO; CRAL/TRIO domain

    4. NM_001014566.1 → NP_001014566.1  uncharacterized protein Dmel_CG33523, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014566.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMM9, Q9VRR4
      Conserved Domains (1) summary
      pfam00635
      Location:29 → 132
      Motile_Sperm; MSP (Major sperm protein) domain

    5. NM_001014567.2 → NP_001014567.1  uncharacterized protein Dmel_CG33523, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014567.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMM9, Q8I0D5
      Conserved Domains (1) summary
      pfam00635
      Location:35 → 138
      Motile_Sperm; MSP (Major sperm protein) domain

    6. NM_001014568.1 → NP_001014568.1  uncharacterized protein Dmel_CG33523, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014568.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I934, Q8IHC4
      Conserved Domains (1) summary
      pfam00635
      Location:1 → 104
      Motile_Sperm; MSP (Major sperm protein) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NF21 M9NF21
    M9PBR6 M9PBR6
    Q8I0D5 Q8I0D5
    Q8I934 Q8I934
    Q8I935 Q8I935
    Q8IGR6 Q8IGR6
    Q8IHC4 Q8IHC4
    Q9VRR4 Q9VRR4

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