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    PVRAP PVR adaptor protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38677, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PVRAPprovided by FlyBase
    Official Full Name
    PVR adaptor proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052406
    Locus tag
    Dmel_CG32406
    See related
    AllianceGenome:FB:FBgn0052406
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13292; CG32406; CG6062; Dmel\CG32406
    Summary
    Enables vascular endothelial growth factor receptor binding activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway; positive regulation of TORC1 signaling; and vascular endothelial growth factor receptor signaling pathway. Predicted to be active in focal adhesion. Is expressed in wing pouch. Orthologous to human TNS4 (tensin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PVRAP in Genome Data Viewer
    Location:
    65A2-65A3; 3-16 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5997208..6026317)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5990308..6019417)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45439 Neighboring gene long non-coding RNA:CR45440 Neighboring gene alpha Karyopherin-4 Neighboring gene uncharacterized protein Neighboring gene yippee interacting protein 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila as Model System to Study Ras-Mediated Oncogenesis: The Case of the Tensin Family of Proteins. Martínez-Abarca Millán A, et al. Genes (Basel), 2023 Jul 23. PMID 37510408, Free PMC Article
    2. EGFRAP encodes a new negative regulator of the EGFR acting in both normal and oncogenic EGFR/Ras-driven tissue morphogenesis. Soler Beatty J, et al. PLoS Genet, 2021 Aug. PMID 34411095, Free PMC Article
    3. Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1. Tran TA, et al. Mol Cell Biol, 2013 Oct. PMID 23878397, Free PMC Article
    4. Retinal Axon Guidance Requires Integration of Eya and the Jak/Stat Pathway into Phosphotyrosine-Based Signaling Circuitries in Drosophila. Hoi CS, et al. Genetics, 2016 Jul. PMID 27194748, Free PMC Article
    5. Spitz from the retina regulates genes transcribed in the second mitotic wave, peripodial epithelium, glia and plasmatocytes of the Drosophila eye imaginal disc. Firth LC, et al. Dev Biol, 2007 Jul 15. PMID 17553483, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables vascular endothelial growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PVR adaptor protein
    Names
    CG32406-PA
    PVRAP-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5997208..6026317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168153.2 → NP_729124.1  PVR adaptor protein [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729124.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRS2
      Related
      FBpp0076745
      Conserved Domains (1) summary
      cl15255
      Location:342 → 435
      SH2; Src homology 2 (SH2) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRS2 Q9VRS2

    Gene LinkOut

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