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    Syn1 Syntrophin-like 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40424, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Syn1provided by FlyBase
    Official Full Name
    Syntrophin-like 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0037130
    Locus tag
    Dmel_CG7152
    See related
    AllianceGenome:FB:FBgn0037130
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7151; CG7152; Dmel\CG7152; DmSYN-1
    Summary
    Predicted to be a structural constituent of muscle. Involved in locomotion and regulation of synaptic assembly at neuromuscular junction. Predicted to be part of syntrophin complex. Is expressed in several structures, including embryonic anal pad; embryonic stomatogastric nervous system; embryonic/larval garland cell; ganglia; and gut section. Used to study muscular dystrophy. Human ortholog(s) of this gene implicated in long QT syndrome; long QT syndrome 12; and sudden infant death syndrome. Orthologous to several human genes including SNTB2 (syntrophin beta 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Syn1 in Genome Data Viewer
    Location:
    78E6-78F1; 3-47 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21745359..21770534, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21738459..21763634, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45957 Neighboring gene long non-coding RNA:CR45958 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene eagle

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Signaling through the dystrophin glycoprotein complex affects the stress-dependent transcriptome in Drosophila. Carney TD, et al. Dis Model Mech, 2023 Jan 1. PMID 36594281, Free PMC Article
    2. Drosophila Syntrophins are involved in locomotion and regulation of synaptic morphology. Nagai R, et al. Exp Cell Res, 2010 Aug 15. PMID 20632467
    3. Combining genome-wide methods to investigate the genetic complexity of courtship song variation in Drosophila melanogaster. Turner TL, et al. Mol Biol Evol, 2013 Sep. PMID 23777628, Free PMC Article
    4. Conservation of components of the dystrophin complex in Drosophila. Greener MJ, et al. FEBS Lett, 2000 Sep 29. PMID 11018515
    5. Embryonic expression patterns of the Drosophila dystrophin-associated glycoprotein complex orthologs. Dekkers LC, et al. Gene Expr Patterns, 2004 Mar. PMID 15161095

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Syn1 and Syn2 are required for locomotion and are involved in regulation of synaptic morphology
      Title: Drosophila Syntrophins are involved in locomotion and regulation of synaptic morphology.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c21754470-21749384 mobile_element_type = transposon:jockey{}1086

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of muscle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic assembly at neuromuscular junction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of dystrophin-associated glycoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of syntrophin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Syntrophin-like 1
    Names
    CG7152-PB
    CG7152-PC
    CG7152-PD
    CG7152-PE
    Syn1-PB
    Syn1-PC
    Syn1-PD
    Syn1-PE
    Syntrophin-1
    syntrophin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21745359..21770534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168937.3 → NP_730686.3  Syntrophin-like 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730686.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNY4
      Conserved Domains (3) summary
      cd00992
      Location:162 → 243
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01258
      Location:292 → 350
      PHsplit_syntrophin; Syntrophin Split Pleckstrin homology (PH) domain
      cl17171
      Location:30 → 61
      PH-like; Pleckstrin homology-like domain

    2. NM_079481.2 → NP_524205.2  Syntrophin-like 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524205.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29QG2, Q9VNY2
      Conserved Domains (3) summary
      cd00992
      Location:163 → 244
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01258
      Location:293 → 351
      PHsplit_syntrophin; Syntrophin Split Pleckstrin homology (PH) domain
      cl17171
      Location:30 → 61
      PH-like; Pleckstrin homology-like domain

    3. NM_001275262.1 → NP_001262191.1  Syntrophin-like 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262191.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGE3
      Conserved Domains (3) summary
      cd00992
      Location:163 → 244
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01258
      Location:293 → 351
      PHsplit_syntrophin; Syntrophin Split Pleckstrin homology (PH) domain
      cl17171
      Location:30 → 61
      PH-like; Pleckstrin homology-like domain

    4. NM_001275263.1 → NP_001262192.1  Syntrophin-like 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262192.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29QG2, Q9VNY2
      Conserved Domains (3) summary
      cd00992
      Location:163 → 244
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01258
      Location:293 → 351
      PHsplit_syntrophin; Syntrophin Split Pleckstrin homology (PH) domain
      cl17171
      Location:30 → 61
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PGE3 M9PGE3
    Q9GT69 Q9GT69
    Q9VNY2 Q9VNY2
    Q9VNY4 Q9VNY4

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