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    PI31 Proteasome inhibitor 31 kDa [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36277, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PI31provided by FlyBase
    Official Full Name
    Proteasome inhibitor 31 kDaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033669
    Locus tag
    Dmel_CG8979
    See related
    AllianceGenome:FB:FBgn0033669
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    8979; cg8979; CG8979; Dmel\CG8979; dmPI31; DmPI31
    Summary
    Predicted to enable endopeptidase inhibitor activity and proteasome binding activity. Involved in several processes, including male gonad development; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and regulation of proteasome assembly. Located in sperm individualization complex. Is expressed in several structures, including adult head; imaginal disc; male germline cell; and testis. Orthologous to human PSMF1 (proteasome inhibitor subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PI31 in Genome Data Viewer
    Location:
    48D5-48D5; 2-65 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11967343..11970115, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7854848..7857620, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44305 Neighboring gene long non-coding RNA:CR44312 Neighboring gene expansion Neighboring gene ADD domain-containing protein 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The FBXO7 homologue nutcracker and binding partner PI31 in Drosophila melanogaster models of Parkinson's disease. Merzetti EM, et al. Genome, 2017 Jan. PMID 27936908
    2. Cofilin Loss in Drosophila Muscles Contributes to Muscle Weakness through Defective Sarcomerogenesis during Muscle Growth. Balakrishnan M, et al. Cell Rep, 2020 Jul 21. PMID 32697999, Free PMC Article
    3. Finding differentially expressed regions of arbitrary length in quantitative genomic data based on marked point process model. Hatsuda H. Bioinformatics, 2012 Sep 15. PMID 22962492, Free PMC Article
    4. PI31 Is an Adaptor Protein for Proteasome Transport in Axons and Required for Synaptic Development. Liu K, et al. Dev Cell, 2019 Aug 19. PMID 31327739, Free PMC Article
    5. Tankyrase Mediates K63-Linked Ubiquitination of JNK to Confer Stress Tolerance and Influence Lifespan in Drosophila. Li P, et al. Cell Rep, 2018 Oct 9. PMID 30304683

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables proteasome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of proteasome assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in sperm individualization complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proteasome inhibitor 31 kDa
    Names
    CG8979-PA
    CG8979-PB
    CG8979-PC
    CG8979-PD
    CG8979-PF
    PI31-PA
    PI31-PB
    PI31-PC
    PI31-PD
    PI31-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11967343..11970115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273976.2 → NP_001260905.1  proteasome inhibitor 31 kDa, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260905.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZD9, Q0E9B8, Q9V637
      UniProtKB/TrEMBL
      A0A0B4KEK7
      Conserved Domains (1) summary
      pfam11566
      Location:23 → 159
      PI31_Prot_N; PI31 proteasome regulator N-terminal

    2. NM_136871.4 → NP_610715.1  proteasome inhibitor 31 kDa, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610715.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZD9, Q0E9B8, Q9V637
      UniProtKB/TrEMBL
      A0A0B4KEK7
      Related
      FBpp0087157
      Conserved Domains (1) summary
      pfam11566
      Location:23 → 159
      PI31_Prot_N; PI31 proteasome regulator N-terminal

    3. NM_001273978.2 → NP_001260907.1  proteasome inhibitor 31 kDa, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260907.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZD9, Q0E9B8, Q9V637
      UniProtKB/TrEMBL
      A0A0B4KEK7
      Conserved Domains (1) summary
      pfam11566
      Location:23 → 159
      PI31_Prot_N; PI31 proteasome regulator N-terminal

    4. NM_165855.3 → NP_725093.1  proteasome inhibitor 31 kDa, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725093.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZD9, Q0E9B8, Q9V637
      UniProtKB/TrEMBL
      A0A0B4KEK7
      Related
      FBpp0087158
      Conserved Domains (1) summary
      pfam11566
      Location:23 → 159
      PI31_Prot_N; PI31 proteasome regulator N-terminal

    5. NM_165854.3 → NP_725092.1  proteasome inhibitor 31 kDa, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725092.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZD9, Q0E9B8, Q9V637
      UniProtKB/TrEMBL
      A0A0B4KEK7
      Related
      FBpp0087159
      Conserved Domains (1) summary
      pfam11566
      Location:23 → 159
      PI31_Prot_N; PI31 proteasome regulator N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEK7 A0A0B4KEK7
    Q9V637.1 Q9V637

    Gene LinkOut

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