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    CG4757 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41330, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4757provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027584
    Locus tag
    Dmel_CG4757
    See related
    AllianceGenome:FB:FBgn0027584
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH05741; Dmel\CG4757; GH05702; GH05741
    Summary
    Enables serine hydrolase activity. Is expressed in adult head. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to several human genes including CES1 (carboxylesterase 1); CES2 (carboxylesterase 2); and CES3 (carboxylesterase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4757 in Genome Data Viewer
    Location:
    86D5-86D5; 3-50 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11161207..11163498)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6986929..6989220)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene UDP-glycosyltransferase family 302 member E1 Neighboring gene UDP-glycosyltransferase family 302 member C1 Neighboring gene UDP-glycosyltransferase family 35 member E1 Neighboring gene UDP-glycosyltransferase family 35 member E2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A rapid genome-wide response to Drosophila melanogaster social interactions. Carney GE. BMC Genomics, 2007 Aug 22. PMID 17714588, Free PMC Article
    2. Decoupled differentiation of gene expression and coding sequence among Drosophila populations. Kohn MH, et al. Genes Genet Syst, 2008 Jun. PMID 18670138
    3. A comparison of the transcriptome of Drosophila melanogaster in response to entomopathogenic fungus, ionizing radiation, starvation and cold shock. Moskalev A, et al. BMC Genomics, 2015. PMID 26694630, Free PMC Article
    4. A kappaB sequence code for pathway-specific innate immune responses. Busse MS, et al. EMBO J, 2007 Aug 22. PMID 17660749, Free PMC Article
    5. Drosophila melanogaster males respond differently at the behavioural and genome-wide levels to Drosophila melanogaster and Drosophila simulans females. Ellis LL, et al. J Evol Biol, 2009 Nov. PMID 19765174

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carboxylesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables serine hydrolase activity HDA PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4757-PA
    CG4757-PB
    NP_001262469.1
    NP_650043.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11161207..11163498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275540.1 → NP_001262469.1  uncharacterized protein Dmel_CG4757, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262469.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9Y141
      Conserved Domains (2) summary
      COG0657
      Location:40 → 204
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:15 → 540
      COesterase; Carboxylesterase family

    2. NM_141786.3 → NP_650043.1  uncharacterized protein Dmel_CG4757, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650043.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9Y141
      Related
      FBpp0081815
      Conserved Domains (2) summary
      COG0657
      Location:40 → 204
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:15 → 540
      COesterase; Carboxylesterase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y141 Q9Y141

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