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    DNaseII Deoxyribonuclease II [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48228, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DNaseIIprovided by FlyBase
    Official Full Name
    Deoxyribonuclease IIprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000477
    Locus tag
    Dmel_CG7780
    See related
    AllianceGenome:FB:FBgn0000477
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7780; dDNase II; Dmel\CG7780; DNase; DNase 1; DNase II; DNase-1; DNase1; dnaseII; dnaseII[lo]
    Summary
    Enables deoxyribonuclease II activity. Involved in nurse cell apoptotic process. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval fat body; embryonic/larval midgut primordium; and endoderm anlage. Orthologous to human DNASE2B (deoxyribonuclease 2 beta) and DNASE2 (deoxyribonuclease 2, lysosomal). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See DNaseII in Genome Data Viewer
    Location:
    90E1-90E1; 3-62 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18019375..18021161)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13845097..13846883)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Rab3 interacting molecule Neighboring gene uncharacterized protein Neighboring gene couch potato Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genetic and developmental analysis of an acid deoxyribonuclease in Drosophila melanogaster. Detwiler C, et al. Biochem Genet, 1978 Dec. PMID 109079
    2. Purification of a lysosomal DNase from Drosophila melanogaster. Gaszner M, et al. Biochem Biophys Res Commun, 1991 Nov 27. PMID 1659816
    3. Drosophila deoxyribonucleases. I. Variation of deoxyribonucleases in Drosophila melanogaster. Boyd JB. Biochim Biophys Acta, 1969 Jan 7. PMID 5763400
    4. DNase II deficiency impairs innate immune function in Drosophila. Seong CS, et al. Cell Immunol, 2006 Mar. PMID 16854402, Free PMC Article
    5. The characterization of a mutant affecting DNA metabolism in the development of D. melanogaster. Stone JC, et al. Can J Genet Cytol, 1983 Apr. PMID 6406021

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DNase II mediates a parthanatos-like developmental cell death pathway in Drosophila primordial germ cells.
      Title: DNase II mediates a parthanatos-like developmental cell death pathway in Drosophila primordial germ cells.
    2. findings indicate that DNaseII can act cell autonomously to degrade DNA during nonapoptotic cell death.
      Title: Cell-autonomous requirement for DNaseII in nonapoptotic cell death.
    3. These results confirm that DNase II and the ability to clear macromolecular DNA is essential for maintaining proper immune function in Drosophila.
      Title: DNase II deficiency impairs innate immune function in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA endonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables deoxyribonuclease II activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deoxyribonuclease II activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deoxyribonuclease II activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables deoxyribonuclease II activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables deoxyribonuclease II activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic DNA fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nurse cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    deoxyribonuclease II
    Names
    CG7780-PA
    DNaseII-PA
    acid DNase
    deoxyribonuclease 1
    NP_650672.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18019375..18021161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142415.3 → NP_650672.1  deoxyribonuclease II [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650672.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JYM9, Q9VED8
      Related
      FBpp0082962
      Conserved Domains (3) summary
      cd09120
      Location:21 → 164
      PLDc_DNaseII_1; Catalytic domain, repeat 1, of Deoxyribonuclease II and similar proteins
      cd09121
      Location:213 → 362
      PLDc_DNaseII_2; Catalytic domain, repeat 2, of Deoxyribonuclease II and similar proteins
      pfam03265
      Location:24 → 360
      DNase_II; Deoxyribonuclease II
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JYM9 Q7JYM9
    Q9VED8 Q9VED8

    Gene LinkOut

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