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    hook hook [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35169, updated on 4-Jan-2025

    Summary

    Official Symbol
    hookprovided by FlyBase
    Official Full Name
    hookprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001202
    Locus tag
    Dmel_CG10653
    See related
    AllianceGenome:FB:FBgn0001202
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10653; dHk; Dmel\CG10653; hk; Hook
    Summary
    Enables microtubule binding activity and small GTPase binding activity. Involved in cytoskeleton-dependent intracellular transport; determination of adult lifespan; and endocytosis. Located in endosome and synapse. Is expressed in adult head; embryonic/larval hemocyte; macrochaeta; and organism. Orthologous to several human genes including HOOK1 (hook microtubule tethering protein 1) and HOOK2 (hook microtubule tethering protein 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See hook in Genome Data Viewer
    Location:
    37B10-37B10; 2-54 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19030844..19033498, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19030844..19033498, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43700 Neighboring gene similar to Deadpan Neighboring gene uncharacterized protein Neighboring gene mind bomb 2 Neighboring gene Catecholamines up Neighboring gene Tetratricopeptide repeat domain 19

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dynein light intermediate chain binding  
    enables microtubule binding  
    enables microtubule binding PubMed 
    enables microtubule binding  
    enables small GTPase binding PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in endosome PubMed 
    located_in synapse PubMed 

    General protein information

    Preferred Names
    hook
    Names
    CG10653-PA
    hook-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19030844..19033498 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057225.4 → NP_476573.1  hook [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476573.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24185, Q9VJ15
      Related
      FBpp0080722
      Conserved Domains (1) summary
      pfam05622
      Location:8 → 675
      HOOK; HOOK protein
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