ck crinkled [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ckprovided by FlyBase
Official Full Name: crinkledprovided by FlyBase
Primary source: FLYBASE:FBgn0000317
Locus tag: Dmel_CG7595
See related: AllianceGenome:FB:FBgn0000317
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 53D10S; anon-35Bb; BG:DS00929.11; br27; CG7595; CK; ck/MyoVIIA; D; D2; Dm 35B; DM7a; Dmel\CG7595; DmVIIa; DmVIIA; DMyoVIIa; Dro35B; ESTS:53D10S; l(1)35Ca; l(2)07130; l(2)35Ca; l(2)br27; l35Ca; Mhc35BC; Myo7A; Myo7B; myosin-7a; myoVIIa; myoVIIA; MyoVIIA; stc; stch
Summary: Enables several functions, including ATP binding activity; cadherin binding activity; and plus-end directed microfilament motor activity. Involved in several processes, including chaeta morphogenesis; instar larval or pupal development; and plasma membrane bounded cell projection organization. Located in several cellular components, including basal cortex; chrorion micropyle; and female germline ring canal outer rim. Part of myosin VII complex. Colocalizes with actin cytoskeleton. Is expressed in several structures, including adult head; follicle cell; germarium; germline cell; and micropyle. Used to study auditory system disease and autosomal recessive nonsyndromic deafness 2. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Usher syndrome (multiple); auditory system disease (multiple); and congenital nystagmus. Orthologous to human MYO7A (myosin VIIA). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 35B8-35B9; 2-50 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (15044963..15057862, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (15044963..15057862, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutations in Drosophila crinkled/Myosin VIIA disrupt denticle morphogenesis.
Title: Mutations in Drosophila crinkled/Myosin VIIA disrupt denticle morphogenesis.
A binding protein regulates myosin-7a dimerization and actin bundle assembly.
Title: A binding protein regulates myosin-7a dimerization and actin bundle assembly.
CK selectively interacts with the initiator caspase DRONC and regulates some of its non-apoptotic functions. Results expose a conserved role for unconventional myosins in transducing caspase-dependent regulation of kinases.
Title: The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles.
Data suggest that Crinkled acts in concert with Wingless targets to orchestrate the proper shaping of denticles in the Drosophila embryonic epidermis.
Title: crinkled reveals a new role for Wingless signaling in Drosophila denticle formation.
domain markedly inhibits the actin-activated ATPase activity of tailless DM7A at low Ca(2+) but not high Ca(2+)
Title: The tail binds to the head-neck domain, inhibiting ATPase activity of myosin VIIA.
Loss of ck/myoVIIA function leads to complete deafness in Drosophila by disrupting the integrity of the scolopidia that transduce auditory signals.
Title: Myosin VIIA defects, which underlie the Usher 1B syndrome in humans, lead to deafness in Drosophila.
myosin VIIA is classified to be a high duty ratio motor
Title: Drosophila myosin VIIA is a high duty ratio motor with a unique kinetic mechanism.
kinetic behavior would allow myosin VIIa to exert and hold tension on actin filaments and, if dimerized, to function as a processive cargo transporter.
Title: Dimerized Drosophila myosin VIIa: a processive motor.
Product identified as myosin VIIA.
Title: Drosophila crinkled, mutations of which disrupt morphogenesis and cause lethality, encodes fly myosin VIIA.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	IDA Inferred from Direct Assay more info	PubMed
enables myosin light chain binding	IPI Inferred from Physical Interaction more info	PubMed
enables plus-end directed microfilament motor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament-based movement	IDA Inferred from Direct Assay more info	PubMed
involved_in antennal development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antennal morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chitin-based larval cuticle pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in filopodium assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in follicle cell microvillus organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing hair organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived wing vein morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in apical cortex	IDA Inferred from Direct Assay more info	PubMed
located_in basal cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in chrorion micropyle	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in female germline ring canal outer rim	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
part_of myosin VII complex	IPI Inferred from Physical Interaction more info	PubMed
part_of myosin complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: crinkled

Names: CG7595-PA; CG7595-PB; CG7595-PC; CG7595-PD; ck-PA; ck-PB; ck-PC; ck-PD; lethal 27 in the black-reduced region; lethal group D2; myosin 7a; myosin 7a heavy chain; myosin VII; myosin VIIa; myosin heavy chain at 35BC; myosin-7a; myosin-VII; mysoin VIIa; stubby chaetae; transcription unit D

NP_001285949.1

EC 5.6.1.8

NP_001285950.1

EC 5.6.1.8

NP_523571.1

EC 5.6.1.8

NP_723895.1

EC 5.6.1.8

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

15044963..15057862 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078847.4 → NP_523571.1 crinkled, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523571.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q6NNF6, Q8T0A9, Q9V3Z6

UniProtKB/TrEMBL

G7H829

Related

FBpp0080283

Conserved Domains (9) summary

smart00139
Location:1701 → 1849

MyTH4; Domain in Myosin and Kinesin Tails

smart00242
Location:64 → 733

MYSc; Myosin. Large ATPases

smart00295
Location:1856 → 2068

B41; Band 4.1 homologues

cd13198
Location:1461 → 1559

FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)

cd13199
Location:2064 → 2159

FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)

cd14473
Location:1355 → 1439

FERM_B-lobe; FERM domain B-lobe

cd01381
Location:77 → 721

MYSc_Myo7; class VII myosin, motor domain

pfam00373
Location:1966 → 2068

FERM_M; FERM central domain

cl17036
Location:1560 → 1624

SH3; Src Homology 3 domain superfamily
NM_165099.3 → NP_723895.1 crinkled, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723895.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q6NNF6, Q8T0A9, Q9V3Z6

UniProtKB/TrEMBL

G7H829

Related

FBpp0080282

Conserved Domains (9) summary

smart00139
Location:1701 → 1849

MyTH4; Domain in Myosin and Kinesin Tails

smart00242
Location:64 → 733

MYSc; Myosin. Large ATPases

smart00295
Location:1856 → 2068

B41; Band 4.1 homologues

cd13198
Location:1461 → 1559

FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)

cd13199
Location:2064 → 2159

FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)

cd14473
Location:1355 → 1439

FERM_B-lobe; FERM domain B-lobe

cd01381
Location:77 → 721

MYSc_Myo7; class VII myosin, motor domain

pfam00373
Location:1966 → 2068

FERM_M; FERM central domain

cl17036
Location:1560 → 1624

SH3; Src Homology 3 domain superfamily
NM_001299021.1 → NP_001285950.1 crinkled, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285950.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q6NNF6, Q8T0A9, Q9V3Z6

UniProtKB/TrEMBL

G7H829

Conserved Domains (9) summary

smart00139
Location:1701 → 1849

MyTH4; Domain in Myosin and Kinesin Tails

smart00242
Location:64 → 733

MYSc; Myosin. Large ATPases

smart00295
Location:1856 → 2068

B41; Band 4.1 homologues

cd13198
Location:1461 → 1559

FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)

cd13199
Location:2064 → 2159

FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)

cd14473
Location:1355 → 1439

FERM_B-lobe; FERM domain B-lobe

cd01381
Location:77 → 721

MYSc_Myo7; class VII myosin, motor domain

pfam00373
Location:1966 → 2068

FERM_M; FERM central domain

cl17036
Location:1560 → 1624

SH3; Src Homology 3 domain superfamily
NM_001299020.1 → NP_001285949.1 crinkled, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285949.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q6NNF6, Q8T0A9, Q9V3Z6

UniProtKB/TrEMBL

G7H829

Conserved Domains (9) summary

smart00139
Location:1701 → 1849

MyTH4; Domain in Myosin and Kinesin Tails

smart00242
Location:64 → 733

MYSc; Myosin. Large ATPases

smart00295
Location:1856 → 2068

B41; Band 4.1 homologues

cd13198
Location:1461 → 1559

FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)

cd13199
Location:2064 → 2159

FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)

cd14473
Location:1355 → 1439

FERM_B-lobe; FERM domain B-lobe

cd01381
Location:77 → 721

MYSc_Myo7; class VII myosin, motor domain

pfam00373
Location:1966 → 2068

FERM_M; FERM central domain

cl17036
Location:1560 → 1624

SH3; Src Homology 3 domain superfamily