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    tamo tamo [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37864, updated on 4-Jan-2025

    Summary

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    Official Symbol
    tamoprovided by FlyBase
    Official Full Name
    tamoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0041582
    Locus tag
    Dmel_CG4057
    See related
    AllianceGenome:FB:FBgn0041582
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    60B; CG4057; Dmel\CG4057
    Summary
    Enables small GTPase binding activity. Involved in regulation of protein import into nucleus. Located in cytoplasm. Is expressed in adult head and organism. Orthologous to several human genes including SPATA2 (spermatogenesis associated 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See tamo in Genome Data Viewer
    Location:
    60B11-60B11; 2-106 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24126638..24133551, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20014161..20021074, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Zinc finger protein RP-8 Neighboring gene N(alpha)-acetyltransferase 35 Neighboring gene long non-coding RNA:CR44826

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tamo selectively modulates nuclear import in Drosophila. Minakhina S, et al. Genes Cells, 2003 Apr. PMID 12653959
    2. The Splicing Factor RNA-Binding Fox Protein 1 Mediates the Cellular Immune Response in Drosophila melanogaster. Nazario-Toole AE, et al. J Immunol, 2018 Aug 15. PMID 29997126, Free PMC Article
    3. Dorsoventral axis formation in the Drosophila embryo--shaping and transducing a morphogen gradient. Moussian B, et al. Curr Biol, 2005 Nov 8. PMID 16271864
    4. SCORE: a computational approach to the identification of cis-regulatory modules and target genes in whole-genome sequence data. Site clustering over random expectation. Rebeiz M, et al. Proc Natl Acad Sci U S A, 2002 Jul 23. PMID 12107285, Free PMC Article
    5. Expanding roles for miRNAs and siRNAs in cell regulation. Nakahara K, et al. Curr Opin Cell Biol, 2004 Apr. PMID 15196554

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tamo modulates the levels of import of Dorsal and other proteins
      Title: Tamo selectively modulates nuclear import in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tamo
    Names
    CG4057-PA
    CG4057-PB
    CG4057-PC
    tamo-PA
    tamo-PB
    tamo-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24126638..24133551 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166664.1 → NP_726426.1  tamo, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E8W9, Q8SZS5, Q9W1A4
      UniProtKB/TrEMBL
      B7YZS3
      Related
      FBpp0072188, FBtr0072281
      Conserved Domains (4) summary
      smart00547
      Location:740 → 764
      ZnF_RBZ; Zinc finger domain
      cd09212
      Location:75 → 158
      PUB; PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins
      sd00029
      Location:742 → 761
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00695
      Location:483 → 603
      vMSA; Major surface antigen from hepadnavirus

    2. NM_138045.2 → NP_611889.1  tamo, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E8W9, Q8SZS5, Q9W1A4
      UniProtKB/TrEMBL
      B7YZS3
      Related
      FBpp0072189, FBtr0072282
      Conserved Domains (4) summary
      smart00547
      Location:740 → 764
      ZnF_RBZ; Zinc finger domain
      cd09212
      Location:75 → 158
      PUB; PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins
      sd00029
      Location:742 → 761
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00695
      Location:483 → 603
      vMSA; Major surface antigen from hepadnavirus

    3. NM_001299898.1 → NP_001286827.1  tamo, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E8W9, Q8SZS5, Q9W1A4
      UniProtKB/TrEMBL
      B7YZS3
      Conserved Domains (4) summary
      smart00547
      Location:740 → 764
      ZnF_RBZ; Zinc finger domain
      cd09212
      Location:75 → 158
      PUB; PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins
      sd00029
      Location:742 → 761
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00695
      Location:483 → 603
      vMSA; Major surface antigen from hepadnavirus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7YZS3 B7YZS3
    Q9W1A4.1 Q9W1A4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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