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    fs(1)Ya female sterile (1) Young arrest [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31263, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fs(1)Yaprovided by FlyBase
    Official Full Name
    female sterile (1) Young arrestprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000927
    Locus tag
    Dmel_CG2707
    See related
    AllianceGenome:FB:FBgn0000927
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2707; Dmel\CG2707; EG:95B7.4; fs(1)73; fs(1)M12; fs(1)Y2; fs(1)Y[a]; Ya; YA
    Summary
    Involved in several processes, including DNA replication; chromosome condensation; and pronuclear fusion. Located in cytoplasm; nuclear envelope; and nuclear lamina. Is expressed in several structures, including female germline cell; ovary; pronucleus; and yolk nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fs(1)Ya in Genome Data Viewer
    Location:
    3B3-3B3; 1-1.5 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2724286..2726577)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2618319..2620610)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene female sterile (1) Yb Neighboring gene vilya Neighboring gene deformed wings

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila nuclear lamina protein YA binds to DNA and histone H2B with four domains. Yu J, et al. Mol Biol Cell, 2002 Feb. PMID 11854412, Free PMC Article
    2. The developmentally regulated Drosophila embryonic nuclear lamina protein 'Young Arrest' (fs(1)Ya) is capable of associating with chromatin. Lopez JM, et al. J Cell Sci, 1997 Mar. PMID 9092946
    3. The Drosophila fs(1)Ya protein, which is needed for the first mitotic division, is in the nuclear lamina and in the envelopes of cleavage nuclei, pronuclei, and nonmitotic nuclei. Lopez JM, et al. Dev Biol, 1994 May. PMID 8174776
    4. Functional dissection of YA, an essential, developmentally regulated nuclear lamina protein in Drosophila melanogaster. Liu J, et al. Mol Cell Biol, 1998 Jan. PMID 9418866, Free PMC Article
    5. A hydrophilic lamin-binding domain from the Drosophila YA protein can target proteins to the nuclear envelope. Mani SS, et al. J Cell Sci, 2003 May 15. PMID 12679383

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest YA function is needed at a control point, following meiosis II and the initiation of the first postmeiotic S phase, which is sensitive to the chromatin condensation state of the haploid meiotic products.
      Title: YA is needed for proper nuclear organization to transition between meiosis and mitosis in Drosophila.
    2. P0/AP3, a ribosomal protein that is also an apurinic/apyrimidinic endonuclease, binds to YA in ovary and embryo cytoplasms
      Title: Interaction of the essential Drosophila nuclear protein YA with P0/AP3 in the cytoplasm and in vitro: implications for developmental regulation of YA's subcellular location.
    3. the hydrophilic lamin-binding domain from the Drosophila YA protein can target proteins to the nuclear envelope
      Title: A hydrophilic lamin-binding domain from the Drosophila YA protein can target proteins to the nuclear envelope.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pronuclear fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with nuclear lamina IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear lamina IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with nuclear lamina IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    female sterile (1) young arrest
    Names
    CG2707-PA
    fs(1)Ya-PA
    young arrest

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2724286..2726577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058145.4 → NP_477493.2  female sterile (1) young arrest [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477493.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25028, Q8T057, Q9W4W0, Q9W4W1
      Related
      FBpp0070463
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25028.4 P25028

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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