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    out outsiders [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32926, updated on 27-Dec-2024

    Summary

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    Official Symbol
    outprovided by FlyBase
    Official Full Name
    outsidersprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259834
    Locus tag
    Dmel_CG8062
    See related
    AllianceGenome:FB:FBgn0259834
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD28120; CG8062; Dmel\CG8062; Out
    Summary
    Predicted to enable monocarboxylic acid transmembrane transporter activity. Involved in germ cell development. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; embryonic hypopharynx; embryonic/larval midgut interstitial cell; gnathal primordium; and somatic trunk mesoderm derivative. Human ortholog(s) of this gene implicated in cataract 47. Orthologous to human SLC16A12 (solute carrier family 16 member 12); SLC16A3 (solute carrier family 16 member 3); and SLC16A5 (solute carrier family 16 member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See out in Genome Data Viewer
    Location:
    18C2-18C2; 1-62 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19310513..19322106, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19204546..19216139, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene small non-coding RNA 763 Neighboring gene uncharacterized protein Neighboring gene nicotinic Acetylcholine Receptor alpha7 Neighboring gene kekkon 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Programmed cell death of primordial germ cells in Drosophila is regulated by p53 and the Outsiders monocarboxylate transporter. Yamada Y, et al. Development, 2008 Jan. PMID 18057102
    2. Identification of X-linked genes required for migration and programmed cell death of Drosophila melanogaster germ cells. Coffman CR, et al. Genetics, 2002 Sep. PMID 12242239, Free PMC Article
    3. A monocarboxylate transporter rescues frontotemporal dementia and Alzheimer's disease models. Xu D, et al. PLoS Genet, 2023 Sep. PMID 37733679, Free PMC Article
    4. Gut cytokines modulate olfaction through metabolic reprogramming of glia. Cai XT, et al. Nature, 2021 Aug. PMID 34290404, Free PMC Article
    5. Cell migration and programmed cell death of Drosophila germ cells. Coffman CR. Ann N Y Acad Sci, 2003 May. PMID 12814944

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings inform models in which signaling between p53 and the Outsiders (out) monocarboxylate transporter are integrated to regulate programmed cell death decisions.
      Title: Programmed cell death of primordial germ cells in Drosophila is regulated by p53 and the Outsiders monocarboxylate transporter.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables monocarboxylic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ectopic germ cell programmed cell death TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monocarboxylic acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    outsiders
    Names
    CG8062-PA
    CG8062-PB
    out-PA
    out-PB
    outsider

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19310513..19322106 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298506.1 → NP_001285435.1  outsiders, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285435.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3F9
      Conserved Domains (2) summary
      cd06174
      Location:45 → 225
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:468 → 621
      MFS_1; Major Facilitator Superfamily

    2. NM_133150.3 → NP_573378.1  outsiders, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573378.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3F9
      Related
      FBpp0074451
      Conserved Domains (2) summary
      cd06174
      Location:45 → 225
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:468 → 621
      MFS_1; Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3F9 Q9V3F9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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