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    NCA3 SUN family protein NCA3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853326, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NCA3
    Official Full Name
    SUN family protein NCA3
    Primary source
    SGD:S000003652
    Locus tag
    YJL116C
    See related
    AllianceGenome:SGD:S000003652; FungiDB:YJL116C; VEuPathDB:YJL116C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in proton motive force-driven mitochondrial ATP synthesis. Located in fungal-type vacuole. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NCA3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (193860..194873, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Pho86p Neighboring gene nucleosome assembly factor ASF1 Neighboring gene tRNA-Ala

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The "SUN" family: UTH1, an ageing gene, is also involved in the regulation of mitochondria biogenesis in Saccharomyces cerevisiae. Camougrand NM, et al. Arch Biochem Biophys, 2000 Mar 1. PMID 10683261
    2. NCA3, a nuclear gene involved in the mitochondrial expression of subunits 6 and 8 of the Fo-F1 ATP synthase of S. cerevisiae. Pélissier P, et al. Curr Genet, 1995 Apr. PMID 7586026
    3. Dynamic post-transcriptional regulation by Mrn1 links cell wall homeostasis to mitochondrial structure and function. Reynaud K, et al. PLoS Genet, 2021 Apr. PMID 33857138, Free PMC Article
    4. SUN family proteins Sun4p, Uth1p and Sim1p are secreted from Saccharomyces cerevisiae and produced dependently on oxygen level. Kuznetsov E, et al. PLoS One, 2013. PMID 24040106, Free PMC Article
    5. Mechanisms of patulin toxicity under conditions that inhibit yeast growth. Iwahashi Y, et al. J Agric Food Chem, 2006 Mar 8. PMID 16506856

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dynamic post-transcriptional regulation by Mrn1 links cell wall homeostasis to mitochondrial structure and function.
      Title: Dynamic post-transcriptional regulation by Mrn1 links cell wall homeostasis to mitochondrial structure and function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in fungal-type cell wall IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SUN family protein NCA3
    NP_012419.1
    • Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the vacuole; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      193860..194873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181549.1 → NP_012419.1  TPA: SUN family protein NCA3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012419.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW68, E9P8T8, P46955
      UniProtKB/TrEMBL
      A6ZQL3, B3LQ01, B5VL59, C7GQ10, C8ZBA3, G2WGQ5, N1P941
      Conserved Domains (1) summary
      pfam03856
      Location:83 → 324
      SUN; Beta-glucosidase (SUN family)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46955.1

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