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    ATG10 E2-like conjugating enzyme [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850684, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ATG10
    Official Full Name
    E2-like conjugating enzyme
    Primary source
    SGD:S000003965
    Locus tag
    YLL042C
    See related
    AllianceGenome:SGD:S000003965; FungiDB:YLL042C; VEuPathDB:YLL042C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    APG10
    Summary
    Enables Atg12 transferase activity. Involved in several processes, including autophagy of mitochondrion; cytoplasm to vacuole targeting by the Cvt pathway; and piecemeal microautophagy of the nucleus. Predicted to be located in phagophore assembly site membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ATG10 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (52087..52590, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L8B Neighboring gene Fps1p Neighboring gene succinate dehydrogenase iron-sulfur protein subunit SDH2 Neighboring gene membrane morphogenesis protein VPS13

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and characterization of a ubiquitin-like system for autophagosome formation. Bae JY, et al. J Microbiol Biotechnol, 2010 Dec. PMID 21193819
    2. The Intrinsically Disordered N Terminus in Atg12 from Yeast Is Necessary for the Functional Structure of the Protein. Popelka H, et al. Int J Mol Sci, 2023 Oct 10. PMID 37894717, Free PMC Article
    3. Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures. Kaiser SE, et al. Nat Struct Mol Biol, 2012 Dec. PMID 23142976, Free PMC Article
    4. Structure of the autophagic E2 enzyme Atg10. Hong SB, et al. Acta Crystallogr D Biol Crystallogr, 2012 Oct. PMID 22993095
    5. Apg10p, a novel protein-conjugating enzyme essential for autophagy in yeast. Shintani T, et al. EMBO J, 1999 Oct 1. PMID 10508157, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables Atg12 transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Atg12 transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in piecemeal microautophagy of the nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein modification by small protein conjugation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein modification by small protein conjugation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagophore assembly site membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E2-like conjugating enzyme
    NP_013058.1
    • Conserved E2-like conjugating enzyme; mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      52087..52590 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181862.1 → NP_013058.1  TPA: E2-like conjugating enzyme [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013058.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A7A0L6, D6VXW4, Q07879
      UniProtKB/TrEMBL
      B3LTD2, C7GRJ9, C8ZCT2, G2WIF5, N1P173
      Conserved Domains (1) summary
      cl40666
      Location:62 → 157
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07879.1

    Gene LinkOut

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