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    DRS1 putative ATP-dependent RNA helicase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850652, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DRS1
    Official Full Name
    putative ATP-dependent RNA helicase
    Primary source
    SGD:S000003931
    Locus tag
    YLL008W
    See related
    AllianceGenome:SGD:S000003931; FungiDB:YLL008W; VEuPathDB:YLL008W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable RNA helicase activity. Involved in rRNA processing and ribosomal large subunit assembly. Located in nucleolus. Part of preribosome, large subunit precursor. Orthologous to human DDX27 (DEAD-box helicase 27). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DRS1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (131729..133987)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene phosphatase Neighboring gene copper metallochaperone COX17 Neighboring gene Lmo1p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A putative ATP-dependent RNA helicase involved in Saccharomyces cerevisiae ribosome assembly. Ripmaster TL, et al. Proc Natl Acad Sci U S A, 1992 Dec 1. PMID 1454790, Free PMC Article
    2. Saccharomyces cerevisiae nucleolar protein Nop7p is necessary for biogenesis of 60S ribosomal subunits. Adams CC, et al. RNA, 2002 Feb. PMID 11911362, Free PMC Article
    3. DRS1 to DRS7, novel genes required for ribosome assembly and function in Saccharomyces cerevisiae. Ripmaster TL, et al. Mol Cell Biol, 1993 Dec. PMID 8247005, Free PMC Article
    4. Sequence analysis of the CEN12 region of Saccharomyces cerevisiae on a 43.7 kb fragment of chromosome XII including an open reading frame homologous to the human cystic fibrosis transmembrane conductance regulator protein CFTR. Miosga T, et al. Yeast, 1996 Jun 15. PMID 8810043
    5. Disruption of ribosome assembly in yeast blocks cotranscriptional pre-rRNA processing and affects the global hierarchy of ribosome biogenesis. Talkish J, et al. RNA, 2016 Jun. PMID 27036125, Free PMC Article

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative ATP-dependent RNA helicase
    NP_013093.1
    • Nucleolar DEAD-box protein required for ribosome assembly and function; including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      131729..133987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181828.1 → NP_013093.1  TPA: putative ATP-dependent RNA helicase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013093.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A7A0P8, D6VXZ4, P32892
      UniProtKB/TrEMBL
      B3LTF9, B5VMT4
      Conserved Domains (1) summary
      COG0513
      Location:232 → 726
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32892.2

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