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    UGA2 succinate-semialdehyde dehydrogenase (NAD(P)(+)) [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852291, updated on 9-Dec-2024

    Summary

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    Official Symbol
    UGA2
    Official Full Name
    succinate-semialdehyde dehydrogenase (NAD(P)(+))
    Primary source
    SGD:S000000210
    Locus tag
    YBR006W
    See related
    AllianceGenome:SGD:S000000210; FungiDB:YBR006W; VEuPathDB:YBR006W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    UGA5
    Summary
    Enables succinate-semialdehyde dehydrogenase [NAD(P)+] activity. Involved in cellular response to oxidative stress; gamma-aminobutyrate shunt; and gamma-aminobutyric acid catabolic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in succinic semialdehyde dehydrogenase deficiency. Orthologous to human ALDH5A1 (aldehyde dehydrogenase 5 family member A1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See UGA2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (247010..248503)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene GPI-anchor transamidase GPI18 Neighboring gene Rcr1p Neighboring gene Dsf2p Neighboring gene Flr1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phenotypic and chemotypic studies using Arabidopsis and yeast reveal that GHB converts to SSA and induce toxicity. Mekonnen DW, et al. Plant Mol Biol, 2016 Jul. PMID 27037708
    2. Characterization of the recombinant succinic semi-aldehyde dehydrogenase from Saccharomyces cerevisiae. Cao J, et al. Yeast, 2014 Oct. PMID 25092794
    3. Isolation and characterization of sake yeast mutants deficient in gamma-aminobutyric acid utilization in sake brewing. Takahashi T, et al. J Biosci Bioeng, 2004. PMID 16233652
    4. Common features and differences in the expression of the three genes forming the UGA regulon in Saccharomyces cerevisiae. Cardillo SB, et al. Biochem Biophys Res Commun, 2011 Jul 15. PMID 21708130
    5. New insights into {gamma}-aminobutyric acid catabolism: Evidence for {gamma}-hydroxybutyric acid and polyhydroxybutyrate synthesis in Saccharomyces cerevisiae. Bach B, et al. Appl Environ Microbiol, 2009 Jul. PMID 19411412, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GAD1, UGA1 and UGA2 mediates thermotolerance by reducing reactive oxygen production.
      Title: GABA shunt mediates thermotolerance in Saccharomyces cerevisiae by reducing reactive oxygen production.
    2. UGA1 and UGA2, are subject to amino acid regulation as it occurs for UGA4.
      Title: Common features and differences in the expression of the three genes forming the UGA regulon in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinate-semialdehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate-semialdehyde dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinate-semialdehyde dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinate-semialdehyde dehydrogenase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinate-semialdehyde dehydrogenase [NAD(P)+] activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gamma-aminobutyrate shunt IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in gamma-aminobutyrate shunt IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gamma-aminobutyric acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gamma-aminobutyric acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gamma-aminobutyric acid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    succinate-semialdehyde dehydrogenase (NAD(P)(+))
    NP_009560.1
    • Succinate semialdehyde dehydrogenase; involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      247010..248503
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178354.1 → NP_009560.1  TPA: succinate-semialdehyde dehydrogenase (NAD(P)(+)) [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009560.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ07, E9PAD1, P38067
      UniProtKB/TrEMBL
      A6ZKV3, B3LND4, B5VDY0, C7GM43, C8Z402, G2W914, N1P9B7
      Conserved Domains (1) summary
      TIGR01780
      Location:37 → 486
      SSADH; succinate-semialdehyde dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38067.2

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